18F-FDG符合线路显像对分化型甲状腺癌复发转移的应用价值
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Value of 18F-FDG dual-head coincidence imaging in the diagnosis of recurrent or metastatic differentiated thyroid carcinoma
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    摘要:

    目的:探讨18F-FDG符合线路(DHC)显像对分化型甲状腺癌(DTC)手术和131I治疗后复发转移的临床随访价值-方法:对28例临床经手术和131I清甲治疗后的DTC患者行18F-FDG DHC显像及131I全身显像,计算其诊断复发转移灶的灵敏度-特异性和准确性-阳性预测值-阴性预测值,并与甲状腺球蛋白检查结果相比较-结果:28例患者中DHC显像真阳性8例,真阴性13例,假阳性1例,假阴性6例,其诊断甲状腺癌复发转移的灵敏度-特异性和准确性-阳性预测值-阴性预测值分别为57.1%-92.8%-75.0%-88.9%-68.4%-当HTg≥10 ng/ml, DHC显像探测复发转移灶以颈淋巴结-骨灵敏度较高-结论:18F-FDG DHC显像对术后和131I清甲治疗后的DTC复发转移诊断有较高的临床价值-

    Abstract:

    Objective:To investigate the value of 18F-fluorodeoxyglucose(FDG) dual-head coincidence imaging in the diagnosis of recurrent and metastatic differentiated thyroid carcinoma. Methods:Twenty-eight patients with differentiated thyroid carcinoma after post-therapy and radiotherapy with 131I were studied with 18F-FDG dual-head coincidence imaging and 131I whole body imaging. The results were analyzed by calculating its sensitivity, specificity,accuracy,positive predicative value(PPV) and negative predicative value(NPV), compared with thyroglobulin detected. Results:There were 8 true positive cases,13 true negative cases,1 false positive case,6 false negative cases in 28 postoperative patients detected by 18F-FDG dual-head coincidence imaging. The sensitivity, specificity, accuracy, positive predicative value and negative predicative value were 57.1%,92.8%,75.0%,88.9% and 68.4%,respectively. while levels of Tg were more than ≥10 ng/ml,the sensitivity of detecting recurrent carcinoma were higher in cervical lymph lode and bone by 18F-FDG dual-head coincidence imaging. Conclusions:18F-FDG dual-head coincidence imaging holds promising clinical value for diagnosis of patients with differentiated thyroid carcinoma after resection and radiotherapy with 131I, especially for the domestic widespread application of SPECT DHC instrument, which can lower the expense of detection practically.

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李少华,王自正,姚薇萱,王 峰,蒋 娥,孟庆乐.18F-FDG符合线路显像对分化型甲状腺癌复发转移的应用价值[J].南京医科大学学报(自然科学版),2007,(12):1483-1486

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  • 收稿日期:2007-04-10
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