Objective:To compare the differences of neuroprotective effect between FTY720 and FK506 on spinal cord injury(SCI). Methods:A total of 48 male rats were divided randomly into 4 groups:①the test group treated with FTY720;②the test group treated with FK506;③the injuried group and ④the control group. While A-C group were enrolled to establish SCI models using Allen method before treated. The neurological function score and immunohistochemical examination were assessed at certain time after injury. Results:The group of FTY720 was better than the group of FK506 in the detection of Inclined Plate Test scores,BBB scales and SEP test. In injury group,a large number of neuronal death could be seen,and pathological changes in treatment group were better than those in injuried group. The pathological changes in the test group treated with FTY720 group was lest. Conclusion:Early using both of FTY720 and FK506 might be capable of treating SCI,and the effect of FTY720 was superior to FK506.