Objective:To observe effects of salviamiltiorr hizabge on inflammatory cytokine in acute necrotic pancreatitis(ANP) in rats. Methods:The acute necrotic pancreatitis rat model was constructed while the Salviamiltiorrhizabge was administrated synchronously. ELISA was then applied to test the concentration of TNF-α and IL-1β and TGF-β in the serum. Results:On the onset of ANP(3 h),TNF-α and IL-1β were richly produced while TGF-β was obviously secreted until the 6 h after the model construction. Salviamiltiorrhizabge inhibited the production of TNF-α and IL-1β,and the expression of TGF-β at 12 h. Conclusion:Salviamiltiorrhizabge could significantly inhibit the secretion of the pro-inflammation cytokine of TNF-α and IL-1β,and the production of TGF-β. It might be involved in the therapeutic mechanism of Salviamiltiorrhizabge in acute necrotic pancreatitis in rats.