炎性因子IL-1?IL-6?IL-10与卵巢过度刺激综合征大鼠的关系
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南京市医学科技发展项目资助(YKK06100)


Correlation of Interleukin-1,Interleukin-6 and Interleukin-10 levels to ovarian hyperstimulation syndrome of rat model
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    摘要:

    目的:检测卵巢过度刺激综合征(OHSS)大鼠体内IL-1-IL-6-IL-10的变化,探讨OHSS的发病机制-方法:将Wistar雌性清洁大鼠随机分成生理盐水组和OHSS组-卵巢过度刺激组皮下注射孕马血清促性腺激素(PMSG)10 IU,每日1次,连续4天,第5天皮下注射100 IU人绒毛膜促性腺激素(HCG)一次建立OHSS模型;对照组皮下注射生理盐水每天1次,连续5天-HCG注射后48 h,取大鼠血-卵巢测IL-1-IL-6-IL-10(酶联免疫法)-结果:OHSS组血和卵巢IL-1均高于对照组,有显著差异(P < 0.05);两组血IL-6-IL-10含量极低,无法测出-OHSS组卵巢IL-10含量显著降低,有统计学意义(P < 0.05)-结论:大鼠OHSS全身症状可能与主要由IL-1介导的炎症相关,而IL-6和IL-10参与卵巢局部炎症-

    Abstract:

    Objective:To investigate the correlation of IL-1,IL-6 and IL-10 levels to ovarian hyperstimulation syndrome of rat model. Methods:Immature female Wistar rats were divided into control group,ovarian hyperstimulation syndrome(OHSS) group. For OHSS group,pregnancy mare serum gonadotropin(PMSG) and human chorionic gonadotropin(HCG) were given to induce OHSS. Forty-eight hours after administration of HCG,the rats were killed and then their ovary,blood samples were obtained for evaluation of interleukins-1,6,10(ELISA). Results:In OHSS group,both serum and ovarian concentrations of IL-1 were statistically significantly higher than those in the control group(P < 0.05). The ovarian concentrations of IL-10 in OHSS group were significantly lower than those in the control group(P < 0.05). Conclusion:These findings suggested that inflammation involving IL-1 in OHSS rats should play an important role in systemic symptoms. IL-6 and IL-10 could contribute to local inflammation of ovary.

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张 蕾,胡娅莉.炎性因子IL-1?IL-6?IL-10与卵巢过度刺激综合征大鼠的关系[J].南京医科大学学报(自然科学版),2008,28(2):181-183219

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  • 收稿日期:2007-08-22
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