血清sFas和sICAM-1的测定对系统性红斑狼疮患者疾病活动性及治疗转归预测价值
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苏州市科技计划项目(苏科计[2007]200号SZD0790)


Study of the serum sFas and sICAM-1 correlate with the disease activity and the value of therapeutic prediction in systemic lupus erythematosus
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    目的:探讨系统性红斑狼疮(SLE)患者血清凋亡调节蛋白sFas和可溶性细胞间黏附分子(sICAM-1)对疾病活动性及治疗转归的预测价值-方法:采用酶联免疫吸附试验(ELISA)检测SLE患者和正常人血清sFas和sICAM-1的水平,分析sFas和sICAM-1的含量与SLE患者的疾病活动度指数SLEDAI和免疫指标(ANA-dsDNA等)的相关性,研究用sFas和 sICAM-1指标判断疾病的活动性,并进行了SLE病例的前瞻性和治疗前后对照研究-结果:SLE患者血清sFas和sICAM-1平均水平分别为4.18 -滋g/L和464.5 -滋g/L,显著高于正常对照组2.27 -滋g/L和190.4 -滋g/L-SLE患者血清sFas和sICAM-1水平活动期均高于非活动期(P < 0.001),ANA高滴度组高于ANA低滴度组,dsDNA抗体阳性组高于dsDNA抗体阴性组,肾损害组高于非肾损害组;且SLE患者血清sFas和sICAM-1水平与SLE患者SLEDAI呈正相关(r = 0.688和r = 0.728)-以非活动性SLE组的x ± s作为评判临界值,同时定量检测sFas( > 4.45 -滋g/L)-sICAM-1( > 438.6 -滋g/L)对SLE活动性的预测具有较好的灵敏度-特异度-结论:sFas和 sICAM-1与SLE发病有关,可反映SLE患者的疾病活动性,同时定量检测可有助于预测患者的病情活动和转归-[关键词] 系统性红斑狼疮; sFas; 可溶性细胞间黏附分子; SLEDAI

    Abstract:

    Objective:To study of the serum sFas and sICAM-1 correlate with the disease activity and the value of therapeutic prediction in systemic lupus erythematosus(SLE). Methods:Serum sFas and sICAM-1 levels in patients with SLE and healthy controls were detected by using a commercially available ELISA system, and the correlation of the levels of sFas and sICAM-1 in SLE patients were analyzed with SLEDAI scores and other immune markers(ANA,ds-DNA etc). The judgment of disease activity with the levels of sFas and sICAM-1 was also studied. Results:The average levels of sFas and sICAM-1 in SLE patients were respectively 4.18 -滋g/L and 464.5 -滋g/L,higher than that in the healthy controls. The sFas and sICAM-1 in the healthy controls were 2.27 -滋g/L and 190.4 -滋g/L. Serum levels of sFas and sICAM-1 were significantly higher in active SLE patients than in inactive patients(P < 0.001). Serum levels of sFas and sICAM-1 were significantly higher in patients with higher concentration of ANA,positive ds-DNA antibody and damaged of renal function than that with lower concentration of ANA,negative ds-DNA antibody and normal of renal function. The serological levels of sFas and sICAM-1 were shown to have a positive correlation with SLEDAI scores(r = 0.688 and r = 0.728). The average levels ± SD of sFas and sICAM-1 in inactive SLE patients were used as the critical value. The quatitative detection of serum sFas( > 4.45 -滋g/L) and sICAM-1(438.6 -滋g/L) had higher sensitivity and specificity to the value of therapeutic prediction. Conclusion:The results suggested that sFas and sICAM-1 should play certain roles in the pathogenesis of SLE,and might be correlated with the disease activity. The quatitative detection of serum sFas and sICAM-1 should be the helpful for therapeutic prediction in systemic lupus erythematosus.

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徐红星,邱德华,宋恒蕊,王慧娟,季晓辉.血清sFas和sICAM-1的测定对系统性红斑狼疮患者疾病活动性及治疗转归预测价值[J].南京医科大学学报(自然科学版),2008,28(2):215-219

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  • 收稿日期:2007-08-22
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