PGP9.5和NPY肽能神经在成人睾丸组织中的分布
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Distribution of PGP9.5 and NPY immunoreactive peptidergic nerves in adult human testes
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    摘要:

    目的:研究蛋白基因产物9.5(protein gene product 9.5,PGP9.5)肽能神经和神经肽Y(neuropeptide Y,NPY)肽能神经在成人睾丸组织中的分布情况。方法:成年男性睾丸标本4例,将其制成5 -滋m厚冰冻切片,运用ABC免疫组织化学方法检测睾丸组织中PGP9.5与NPY肽能神经纤维的分布。结果:PGP9.5肽能神经纤维主要分布于睾丸间质中,其与曲细精管及Leydig细胞存在较为紧密的联系;NPY肽能神经纤维主要分布于睾丸血管周围,生精小管管周也可见部分分布,NPY神经纤维分布密度低于PGP9.5神经纤维。结论:人睾丸组织内分布着PGP9.5和NPY肽能神经纤维,精索神经通过这些神经纤维实现其对精子发生过程的调控。

    Abstract:

    Objective:To study the distribution patterns of PGP9.5 and NPY immunoreactive(IR) peptidergic nerves in adult human testes. Methods:Four testes from adult males were processed for 5 -滋m thick frozen sections. Antibodies against protein gene product(PGP) 9.5 and neuropeptide Y(NPY) were used for immunohistochemical detection of peptidergic nerves in the human testes. Results:PGP9.5-IR fibers were mainly distributed in the testicular interstitium,in close association with seminiferous tubules and Leydig cell nests. The majority of the NPY-IR nerves were observed around intratesticular blood vessels,but the walls of the seminiferous tubules were also innervated. The density of PGP9.5 immunoreactive nerve was stronger than that of NPY. Conclusion:The presence of peptidergic nerves in the human testes provides anatomic evidence for involvement of the spermatic nerves in spermatogenesis regulation.

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宗益平,顾 民,龚永光,陈琛君.PGP9.5和NPY肽能神经在成人睾丸组织中的分布[J].南京医科大学学报(自然科学版),2008,28(3):327-329334

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  • 收稿日期:2007-10-17
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