Objective:To study the relationship between functional genetic variants of IL-1B(T-31C,C-511T) and IL-1RN genes and the susceptibility of cervical cancer. Methods:The case-control study was conducted in Jiangsu female population,including 273 cervical cancer cases and 402 cancer-free controls frequency-matched by age and residential areas. Genotypes were determined by PCR-the restriction length polymorphism(PCR-RFLP) assays. Results:The differences of IL-1B T-31C and C-511T genotype frequencies between cases and controls were not statistically significant. After adjusted age and residences,the Logistic regression analysis revealed that the increased risk of cervical cancer was associated with IL-1B -511TT and -511CT variant genotypes(OR=1.93,95% CI=1.00-3.72 for CT genotypes;OR=2.15,95%CI=1.02-4.53 for TT genotypes),compared with the -511CC genotype. Stratified analysis indicated that IL-1B T-31C variant genotypes were statistically associated with cervical cancer risk in the subjects with more than 49 years old(OR=1.72,95%CI=1.01-2.93),pregnancy frequency ≥2(OR=1.83,95%CI=1.07-3.11) and living in countryside(OR=1.63,95%CI=1.04-2.54). No significant association was observed between polymorphisms of IL-1RN gene and cervical cancer risk. Conclusion:These findings supported the hypothesis that the functional genetic variants of IL-1B C-511T might contribute to the cervical carcinogenesis in Jiangsu population.