BVT.2733对肥胖小鼠胰岛素抵抗及炎症指标的影响
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国家自然科学基金资助(30570878)


The effect of BVT.2733 on insulin resistance and inflammation in obesity mice
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    摘要:

    目的:观察BVT.2733对饮食诱导的肥胖小鼠胰岛素抵抗及炎症指标的影响-方法:建立饮食诱导的肥胖模型小鼠,并将其分为肥胖组和BVT.2733治疗组-肥胖组给予安慰剂;治疗组给予BVT.2733灌胃两周,另设正常饲养的小鼠为正常组,检测小鼠体内代谢及炎症相关指标,观察三组小鼠在胰岛素抵抗以及炎症方面的差异-结果:与正常组相比,肥胖组小鼠脂肪细胞明显增大,体重增加,空腹血糖-血清胰岛素及TNF-α升高,脂肪组织TLR4 mRNA表达增高,经BVT.2733治疗后,肥胖鼠脂肪细胞体积减小,体重减轻,空腹血糖-血清胰岛素明显下降,脂肪组织TLR4 mRNA表达减少,而血TNF-α没有显著变化-结论:BVT.2733能改善肥胖小鼠的胰岛素抵抗并且降低脂肪组织TLR4 mRNA的表达,而对于血清TNF-α水平没有明显的影响-

    Abstract:

    Objective:To investigate the effect of BVT.2733 on insulin resistance(IR) and inflammation in diet-induced obesity(DIO)mice. Methods:Male mice were divided into normal mice and model mice after fed with normal diet and high-fat diet for 20 weeks,respectively. The model mice were subdivided into BVT.2733 mice administrated with BVT.2733 and obesity mice with placebo for 2 weeks. Indexes related with metabolism and inflammation were measured. Results:Compared with normal mice,adipocytes were significantly enlarged in obesity mice,and body weight also increased. Similarly,blood glucose,serum insulin and TNF-α,the expression of TLR4 mRNA in adipose tissue were all increased. After administration of BVT.2733,adipocytes were diminished; body weight,blood glucose,serum insulin,and the expression of TLR4 mRNA in adipose tissue were all decreased. But there was no significant change in serum TNF-α. Conclusion:BVT.2733 can improve IR and decrease the expression of TLR4 mRNA in adipose tissue,but have little effect on serum TNF-α in DIO mice.

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朱 亭,谢 宇,刘 娟,钟 毅,丁国宪. BVT.2733对肥胖小鼠胰岛素抵抗及炎症指标的影响[J].南京医科大学学报(自然科学版),2008,28(8):968-972

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  • 收稿日期:2008-01-16
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