甲状腺乳头状癌伴神经内分泌分化细胞的超微结构观察
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江苏省南通市社会发展科技计划资助项目(S5010)


Ultrastructure observation of thyroid papillary carcinoma with neuroendocrine differentiation
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    目的:观察甲状腺乳头状癌伴神经内分泌分化细胞的超微结构特征-方法:对手术切除石蜡包埋的103例甲状腺乳头状癌,分别进行CgA-Syn-NSE免疫组化标记,CgA-Syn-NSE阳性的乳头状癌66例分别进行电镜观察-临床病理参数包括:乳头状癌细胞分化程度-核特征-砂粒体-年龄-肿瘤直径-淋巴结转移-包膜及周围组织侵犯-用STATA8.0医学统计软件对资料进行统计分析-结果:18.2%的甲状腺乳头状癌病例电镜下可找到神经内分泌颗粒-乳头状癌细胞分化程度及肿瘤的大小与神经内分泌分化有关(P < 0.05),其余参数与神经内分泌分化无关-结论:部分甲状腺乳头状癌存在神经内分泌分化现象,伴神经内分泌分化的肿瘤组织分化较差-体积较大-

    Abstract:

    Objective:To observe the ultrastructure feature of thyroid papillary carcinoma with neuroendocrine differentiation. Methods:The paraffin-embedded tissues were used,including 103 cases with thyroid papillary carcinoma,all of which were marked with CgA,Syn and NSE by immunohistochemistry, respectively. Those 66 cases of papillary carcinoma with positive expression of CgA,Syn,NSE were examined by electron microscope. The clinical parameters included cellular differentiation degree, nucleus feature,age,psammoma,tumor diameter,metastasis of lymph nodes,tumor capsule and surrounding-tissue invasion. STATA8.0 medical statistic software was adopted in statistical analysis. Results:18.2% cases with thyroid papillary carcinoma found neuroendocrine particles under the electron microscope. Cellular differentiation degree of papillary carcinoma and the tumor size had relevance to the neuroendocrine differentiation(P < 0.05),but the other parameters had no relevance to neuroendocrine differentiation. Conclusion:The phenomenon of neuroendocrine differentiation exists in partial cases with thyroid papillary carcinoma, and the tissues of thyroid papillary carcinoma with neuroendocrine differentiation have poor differentiation and large tumor size.

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陈旭东,何 松,陆晓云,喻朝霞,戴瑜珍,周建云.甲状腺乳头状癌伴神经内分泌分化细胞的超微结构观察[J].南京医科大学学报(自然科学版),2008,28(8):1022-1026

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  • 收稿日期:2008-02-20
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