Objective:To investigate expressions of human ZRT/IRT-like protein(hZIP1) and cation diffusion facilitator(CDF,ZnT1) mRNAs, study the relationship between Zinc,Zinc transporters and leukemia, and understand its application at precaution,diagnosis and therapy of leukemia. Methods:the experiment objects were divided into the acute myelocytic group, chronic myelocytic leukemia, control group and cell line group. Expressions of hZIP1 and ZnT1 mRNAs were analyzed by RT-PCR. Zinc level in supernatant of bone marrow were measured by flame atomic absorption spectrometry(FAAS) expression. Results:Expression of hZIP1 mRNA of the mononuclearcell in bone marrow was detected. There was no significant difference among incipient group,relapsed group,complete remission group and control group(P > 0.05). Expression of ZnT1 mRNA of the mononuclearcell in bone marrow was detected,and its expression in incipient group and relapsed group were remarkably higher than those in complete-remission group and control group(P < 0.05). The results in cell strains, K562 and HL60, accorded with those in clinical collections. The Zinc levels in supernatant of bone marrow in incipient group and relapsed group were remarkably higher than those in control group and complete remission group(P < 0.05). Conclusion:The hZIP1 plays role in regulating Zinc balance of cells inside and outside,but it has no significant relevance with Zinc regulation when leukeamia occurs. ZnT1 is a significant gene in regulating Zinc level, and has significant relevance with Zinc regulation of the mononuclearcell in bone marrow when leukeamia occurs. The expression of ZnT1 in the bone marrow and the Zinc level in supernatant of bone marrow decreased after therapy suggesting the improvement condition of patients.