微粒体甘油三酯转运蛋白MTP-493G/T基因多态性与冠心病的研究
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江苏省教育厅项目资助(01KJB320006)


The study on microsomal triglyceride transfer protein -493G/T gene polymorphism in non-diabetic patients with coronary heart disease
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    目的:探讨中国汉族人群微粒体甘油三酯转运蛋白(microsomal triglyceride transfer protein,MTP)-493G/T基因多态性与冠心病患病风险的关系-方法:采用聚合酶链反应- 限制性片段长度多态性(PCR-RFLP)方法,测定335例非糖尿病冠心病患者和206例无冠心病对照者MTP-493G/T基因多态性-比较两组MTP-493G/T的基因型与等位基因频率的差别,同时观察MTP-493G/T对血脂参数的影响-结果:在中国江苏汉族人群中发现三种基因型,GG型发生频率最高,GT型次之,TT型发生频率最低-冠心病组TT 基因型频率(6%)高于对照组(3%)(P < 0.05),且T等位基因频率(19%)亦明显高于对照组(12%)(P < 0.01)-各基因型与冠状动脉病变支数无明显相关性-TT基因型TG-LDL-C水平高于GG型(P < 0.05),而TC-HDL-C和LP(a)水平在两者间无统计学差异(P > 0.05)-多因素Logistic回归分析显示TT基因型的OR值为2.14(95%CI 1.22~6.56,P = 0.014),是独立的危险因素,不依赖TT基因型升高TG-LDL-C的作用-结论:微粒体甘油三酯转运蛋白-493TT基因型可能与冠心病易感性有关,其作用不依赖于TT基因型对TG-LDL-C的影响-

    Abstract:

    Objective:To investigate the relationship between the coronary heart disease and the microsomal triglyceride transfer protein(MTP)-493G/T gene polymorphism. Methods:There was a case-control study,which enrolled 335 non-diabetic patients with coronary heart disease(CHD) and 206 control subjects without CHD. The genotype and allele frequencies of MTP-493G/T gene polymorphism were detected by polymerase chain reaction-restricted fragments length polymorphism(PCR-RFLP). Results:The highest frequency of MTP-493G/T genetic variation was GG genotype; the second was GT genotype; and the lowest was TT genotype in Han population of Jiangsu Province,China. Both the TT genotype frequency(6%) and the “T” allele frequency(19%) in the patients with CHD were higher than those in the control(3% and 12%), respectively(P < 0.05). But there wasn’t a significant correlation between MTP-493G/T genotypes and the number of significantly diseased vessels. The TT genotype had the higher TG and LDL-C level(P < 0.05) than GG genotype. In multiple Logistic regression analysis,the TT genotype odds ratio for coronary heart disease was 2.14(95%CI 1.22~6.56,P = 0.014). Conclusion:The TT genotype of MTP-493G/T genetic variation might increase the risk of coronary heart disease, independent of lipid and lipoprotein factors.

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李瑞洁,朱铁兵,倪国贞,杨志健,王连生,曹克将,马文珠.微粒体甘油三酯转运蛋白MTP-493G/T基因多态性与冠心病的研究[J].南京医科大学学报(自然科学版),2008,28(8):998-1002

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  • 收稿日期:2007-12-27
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