丹参多酚酸盐对猪急性心肌梗死后心功能及侧枝循环形成有促进作用
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江苏省自然科学基金资助(BK2007254);上海绿谷制药有限公司科研基金


Promotion of heart function and collateral blood vessel of salvianolate on acute myocardial infarction in swines
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    摘要:

    目的:观察丹参多酚酸盐(salvianolate)对猪急性心肌梗死的治疗作用-方法:苏中幼猪21只,随机分为高剂量-低剂量组和对照组,3组均经开胸结扎冠状动脉左前降支制作心肌梗死模型,造模成功后,两组治疗组(高剂量组:250 ml 5%GS + 400 mg 丹参多酚酸盐;低剂量组:250 ml 5%GS + 200 mg丹参多酚酸盐)结扎后当天开始经静脉途径静滴,对照组经静脉途径应用250 ml 5%GS静滴,均为1次/天,疗程7天-结扎后4周行冠状动脉造影-门控心肌显像评价侧支循环和心功能,然后处死动物,取心脏标本,行免疫组化检查-结果:①冠状动脉造影显示:治疗组梗死区侧枝循环明显优于对照组,尤以高剂量组更为显著;②门控心肌显像:两治疗组的左室射血分数(LVEF)都高于对照组;③免疫组化结果显示:两治疗组的毛细血管密度明显大于对照组,但高剂量组与低剂量组之间无显著差异-两治疗组的功能血管密度也明显大于对照组,且高剂量组明显优于低剂量组(P < 0.05)-结论:静脉应用丹参多酚酸盐能够促进梗死心脏心功能改善和促进血管再生,能促进侧支血管的生成-

    Abstract:

    Objective:To study the therapeutical effects of salvianolate on acute myocardial infarction(AMI) in swines. Methods:Twenty-one young swines were divided into high-dose,low-dose and control group randomly(n = 7,each group). AMI models were made by deligating anterior descending branch as myocardial infarction model. Salvianolate 400 mg + 5% GS 250ml or salvianolate 200 mg + 5%GS 250 ml was injected into swines through the vein once dayly immediately after coronary artery deligated for 7 days in high-dose,low-dose and control group, respectively. Four weeks after operation,coronary bypass circuit and LVEF were evaluated by coronary arteriongraphy,immunohistochemistry and gated myocardial perfusion imaging, respectively. Results:①Coronary arteriongraphy:The circulation of infarction region of therapic group was better than that of control group obviously,especially in high dose group; ②Gated myocardial perfusion imaging:LVEF in two therapic groups was higher than that in control group;③Immunohistochemistry:capillary density of therapic group was significantly higher than that of control group,but there were no significant differences between high-dose and low-dose groups. Similarly,function density of treatment groups also significantly higher than that of control group, which also was higher in the high-dose group than that in low-dose group. Conclusion:Therapeutical effect of salvianolate on acute myocardial infarction(AMI) in swines through the vein is significant. Salvianolate therapy can improve heart function and promote blood vessel regeneration,promote formn of collateral blood vessel.

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王明伟,唐建金,王连生,陈 波,曹克将.丹参多酚酸盐对猪急性心肌梗死后心功能及侧枝循环形成有促进作用[J].南京医科大学学报(自然科学版),2008,28(9):1120-1123

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  • 收稿日期:2008-03-29
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