7.0T Micro MRI 观察丝裂霉素C预防硬膜外粘连的效果研究
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:


Experimental study on prevention of peridural adhesion with topical mitomycin C by 7.0T Micro MRI
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:应用7.0T Micro MRI探讨预防椎板切除后硬膜外粘连实验研究中丝裂霉素C(MMC)的理想浓度及其使用安全性-方法:30只SD大鼠随机分成5组,每组6只-分别切除L1椎板,术中各组分别以棉片浸透生理盐水(A组)或0.1 mg/ml(B组)-0.3 mg/ml(C组)-0.5 mg/ml(D组)-0.7 mg/ml(E组)的MMC,置于裸露的硬脊膜后5 min-应用MMC前后分别对大鼠行体感诱发电位测定-术后4周处死大鼠取手术段脊柱,分别做Micro MRI扫描-瘢痕组织面积测定-肉眼观察硬脊膜与后方瘢痕组织粘连情况-结果:A组标本硬膜外瘢痕组织致密,瘢痕面积大,与硬脊膜形成紧密粘连-B组和C组标本硬膜外瘢痕组织不致密,瘢痕面积减小,与硬脊膜部分粘连-D组和E组标本硬膜外瘢痕组织不致密,瘢痕面积更小,与硬脊膜未形成明显粘连-大鼠应用MMC前后体感诱发电位无明显改变-结论:局部应用浓度为0.5 mg/ml的MMC能有效减少硬膜外瘢痕组织增生,避免椎板切除术后硬膜外瘢痕粘连,并且安全-0.5 mg/ml浓度的MMC可能是椎板切除后预防硬膜外粘连理想的浓度选择-

    Abstract:

    Objective:To study the suitable concentration and the security of topical mitomycin C(MMC) in preventing postlaminectomy peridural adhesion by 7.0T Micro MRI. Methods:Laminectomies were performed at L1 in 30 rats. Cotton pads soaked either with 0.1 mg/ml(group B),0.3 mg/ml(group C),0.5 mg/ml(group D),0.7 mg/ml(group E) MMC,or saline(group A) were applied to the operative sites for five minutes. To determine the somatosensory evoked potential(SEP), the rats were killed 4 weeks after surgey. The specimens were prepared for determination of the degree of scar adhesion according to Rydell method and the area of the scar with MRI. Results:No obvious adhesion were found in group D and group E. Severe peridural adhesion were formed in the control group(group A). The area of the scar with Micro MRI in group D and E showed significant decrease. The SEP did not alter obviously. Conclusion:0.5 mg/ml MMC may be suitable concentration in preventing postlaminectomy peridural adhesion.

    参考文献
    相似文献
    引证文献
引用本文

陆圣华,曹晓建,王立新,孙 钰,滕皋军,臧凤超.7.0T Micro MRI 观察丝裂霉素C预防硬膜外粘连的效果研究[J].南京医科大学学报(自然科学版),2008,28(10):1263-1266

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2008-05-09
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期:
  • 出版日期:
通知关闭
郑重声明