1800株结核分枝杆菌对10种抗结核药物耐药分析
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Surveillance of 10-drug-resistant tuberculosis in Nanjing Chest Hospital
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    目的:了解住院结核患者常用10种抗结核药物的耐药趋势-方法:以南京市胸科医院2001年至2006年的培养阳性结核分枝杆菌为本次研究对象,用绝对浓度法做RFP-INH-SM-EMB-DP-OFLX-PAS-KM-TH1321和CPM10种药物的药敏试验-结果:共有耐药菌株1800例,总耐药率70%,耐多药率为54.9%-结论:结核分枝杆菌对多种药物的耐药性有差异-该院结核分枝杆菌对部分药物的耐药性流行水平有上升趋势,获得了该院耐药性水平资料,对临床用药具有重要的必要性和指导性-

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    Objective:To collect the data of drug resistance to evaluate the prevalence trend of 10 anti-tuberculosis drugs commonly.Methods:The study objectives were from 2001 to 2006. Susceptibility tests(absolute concentration methods for INH,SM,RFP,EMB,TH1321,PAS,AN,KM,OFLX and CPM) were done in all specimens. Results:1800 tuberculosis cases involved in the study. The culture positive rate was 70%. The rate of the tuberculosis anti-multidrugs was 54.9%. Conclusion:The rate of the tuberculosis mutidrug resistant is very different. Some of drug’s resistance trend were rising yearly. The anti-tuberculosis drug resistant surveillance were established. The reliable data on the status of anti-tuberculosis drug resistance results provided the evidences for improvement and assessment on TB control and clinical drug use.

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丁 昊,陈宇炼.1800株结核分枝杆菌对10种抗结核药物耐药分析[J].南京医科大学学报(自然科学版),2008,28(10):1361-1364

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  • 收稿日期:2008-04-22
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