MIF-173位点单核苷酸多态性与影响前列腺癌预后因素关系的研究
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江苏省卫生厅"135"重点学科基金资助(0151)


Association of polymorphisms in MIF-173 genotypes and prognosis factors of prostate cancer
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    目的:研究巨噬细胞移动抑制因子(macrophage migration inhibitory factor,MIF)-173位点单核苷酸多态性与影响前列腺癌预后因素的关系-方法:应用聚合酶链反应限制性片段长度多态性(PCR-RFLP)分析259例前列腺癌患者MIF基因-173位点的多态性,比较不同基因型与前列腺癌患者的前列腺癌特异性抗原(PSA)-Gleason评分-临床分期的关系-结果:MIF-173*C等位基因与PSA-Gleason评分-临床分期具有显著相关性(adjusted OR = 4.39,10.73,15.68;95%CI:2.43~7.93,5.36~21.50,7.40~33.23)-结论:MIF-173*C等位基因可能与前列腺癌的预后有关,携带MIF-173*C等位基因的前列腺癌患者可能预后较差-

    Abstract:

    Objective:To investigate the potential association between the polymorphisms in MIF-173 genotypes and prognosis factors(PSA value,Gleason score and clinical stage) of prostate cancer(PCa). Methods:The polymorphisms of MIF-173 sites were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) technique using genomic DNA isolated from peripheral blood. The association between the prognosis factors(PSA value,Gleason score and clinical stage) of PCa and different genotypes was evaluated. Results:The MIF-173*C variant allele was associated with higher PSA value of the PCa(adjusted OR =4.39,95%CI:2.43-7.93). It was noted that the MIF-173*C variant allele was associated with higher Gleason score and later clinical stage of PCa patients(adjusted OR = 10.73,95%CI:5.36-21.50[adjusted OR = 15.68,95%CI:7.40-33.23,respectively). Conclusion:The results demonstrated that the MIF-173 G to C variant influenced the PSA value,Gleason soccer and clinical stage of PCa. The MIF-173 G to C variant might have a joint effect on the risk of worse prognosis of PCa.

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丁冠雄,冯宁翰,宋宁宏,徐 郑,张 炜,吴宏飞,华立新. MIF-173位点单核苷酸多态性与影响前列腺癌预后因素关系的研究[J].南京医科大学学报(自然科学版),2008,28(11):1406-1409

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  • 收稿日期:2005-05-30
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