Clusterin在乳腺癌中的表达及临床意义
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The expression of Clusterin protein in breast carcinoma and its clinical significance
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    摘要:

    目的:探讨凋亡抑制因子Clusterin在乳腺癌组织中的表达及临床意义-方法:应用免疫组织化学法检测60例乳腺癌-10例乳腺良性病变和10例乳腺正常组织中Clusterin的表达情况,并探讨Clusterin表达与乳腺癌各临床病理学参数间的关系-结果:Clusterin在乳腺正常组织-乳腺良性病变及乳腺癌组织中的阳性表达率分别为0%-10%及78.33%,乳腺癌组织中的Clusterin表达水平明显高于乳腺良性病变及乳腺正常组织(均P < 0.01);Clusterin在乳腺癌中的表达与组织学分级-淋巴结转移相关(P < 0.05),与年龄-肿瘤直径及临床分期无关;在乳腺癌组织中Clusterin与ER-PR的表达负相关,与C-erbB-2的表达无明显相关,与p53-Ki67的表达呈正相关-结论:Clusterin可能通过抑制细胞凋亡在乳腺癌的发生发展中发挥重要作用,并有可能成乳腺癌治疗的新靶点-

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    Objective:To investigate the protein expression of Clusterin in breast cancer and its clinical significance. Methods:Clusterin expression were examined by immunohistochemical staining method in 60 cases with breast cancer,10 cases with benign pathological changes and 10 cases with normal breast tissues. Results:The positive rates of Clusterin in normal breast tissues,benign pathological changes and breast cancer tissues were 0%,10% and 78.33%, respectively. The expression of Clusterin in breast cancer was much higher than that in normal breast tissues(P < 0.05) and benign pathological changes(P < 0.05). The expression of Clusterin in breast cancer tissues was closely related to histological type(P < 0.05) and lymph node metastasis(P < 0.05). but no correlated to the age,tumor size and clinical stage. There was a negative correlation between ER,PR and Clusterin. There was no correlation between C-erbB-2 and Clusterin. There was a positive correlation between p53,Ki67 and Clusterin. Conclusion:Clusterin may play an important role in the biological characteristics of breast cancer by the antiapoptosis pathway. It may be used as a potential therapeutic target for breast cancer.

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黄 悦,赵建华,黄文斌. Clusterin在乳腺癌中的表达及临床意义[J].南京医科大学学报(自然科学版),2008,28(11):1453-1456

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  • 收稿日期:2008-05-27
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