Objective:To study the relationship between CT Staging and CT enhancement of gastric cancer and tumor angiogenesis and provide useful information for clinic therapy. Methods:Enhanced two-stage spiral CT scanning was given before operation to 30 cases who suffered from gastric cancer and were confirmed pathologically after operation. The 30 cases include 24 men and 6 women (average age was 63). CT enhancement values of pathologic region were determined. Tumor specimens of 30 cases were collected after operation. Two-step CD 34 mono-clone antibody and VEGF mono-clone antibody immunological and histo-chemical staining were performed on corresponding research area. TNM and CT staging were also performed based on clinical,CT and pathological findings. Statistical research was carried out on CT enhancement values,CT staging,TNM staging,pathological grading and results of CD 34 and VEGF staining. Results:Conformity rate of TNM staging and CT staging of 30 cases of gastric cancer was 90%. CT enhancement value was positively correlated with TNM and CT staging. CT enhancement value was positively linearly correlated with MVD. Its equation was Y = 49.4125+0.5067X. Difference of CT enhancement values between VEGF high and low expression groups was significant(P < 0.05). There was no relation between pathological grading and CT enhancement value(P > 0.05). Conclusion:Staging can be made by CT presentation before operation. CT enhancement value can reflect tumor angiogenesis of gastric cancer. Pathological grading has no direct assistance in the study of CT enhancement value.