GPX3启动子rs8177412基因多态性与脑梗死的相关性研究
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The Correlative study Between rs8177412 of promoter Polymorphisms in the Plasma Glutathione Peroxidase(GPX-3) gene and arterial ischemic stroke
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    目的:探讨血浆谷胱甘肽过氧化酶(Plasma Glutathione Peroxidase, GPX-3)启动子rs8177412位点基因多态性与脑梗死的相关性-方法:采用聚合酶链反应-连接酶检测方法(PCR-LDR)对94例脑梗死患者和80例健康对照者进行GPX-3启动子基因多态性分析-结果:脑梗死患者组中rs8177412位点TC+CC基因型频率分别高于对照组(P < 0.05),其C等位基因频率亦高于对照组(P < 0.05)-经多项非条件logistic回归分析提示GPX-3启动子rs8177412携带C等位基因可能为脑梗死的独立危险因素-结论:GPX-3启动子rs8177412基因多态性与脑梗死的发生有关,可能是脑梗死的一个重要危险因素-

    Abstract:

    Objectives:To investigate the correlation between the rs8177412 of promoter polymorphisms in the plasma Glutathione Peroxidase(GPX-3) gene and arterial ischemic Stroke. Methods:Ninety four patients(patient group) with arterial ischemic stroke and eighty healty subjects(control group) were recruited in the study, and promoter polymorphisms of the plasma Glutathione Peroxidase(GPX-3) gene were detected using polymerase chain reaction and ligase detection reaction(PCR-LDR). Results:At rs8177412 site of the Plasma Glutathione Peroxidase(GPX-3) Promoter Gene, the frequency of TC+CC-type and the frequency of C alleles respectively were increased in the patient group than that in the control group(P < 0.05). Conclusions:There were some relationships between rs8177412 of promoter polymorphisms in the plasma glutathione peroxidase(GPX-3) gene and arterial ischemic Stroke, and they may be an important risk factor for stroke.

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赵 中,黄开梅,陈伟贤,高炳忠,周 沁,邱晨红,杨义伟. GPX3启动子rs8177412基因多态性与脑梗死的相关性研究[J].南京医科大学学报(自然科学版),2009,29(2):186-189

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  • 收稿日期:2008-10-06
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