活性维生素 D缺乏导致牙齿和下颌骨的发育障碍
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江苏省卫生厅基金资助(H200627)


Active vitamin D deficiency resulted in defects of tooth and mandible development
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    目的:为了检测活性维生素D缺乏及其母乳成分的改变是否影响小鼠下颌骨以及牙齿的发育-方法:通过采用X线摄影-微CT和组织学等方法比较分析25羟维生素D3的1α羟化酶杂合子[1α(OH)ase+/-]和纯合子[1α(OH)ase-/-]母鼠所喂养的纯合子和杂合子小鼠下颌骨以及牙齿的表型差异-结果:母乳中的钙水平在1α(OH)ase-/-母鼠较1α(OH)ase+/-母鼠为低-1α(OH)ase-/-仔鼠的牙量和骨量较同窝1α(OH)ase+/-仔鼠明显下降,而由1α(OH)ase-/-母鼠所喂养仔鼠的牙量和下颌骨骨量比由1α(OH)ase+/-母鼠喂养的仔鼠要低-由1α(OH)ase+/-母鼠所喂养的1α(OH)ase+/-仔鼠牙量和下颌骨量最高,而由1α(OH)ase-/-母鼠所喂养的1α(OH)ase-/-仔鼠牙量和下颌骨量最低-结论:活性维生素D和高乳钙摄入各自具有刺激下颌骨和牙齿矿化和发育的作用,又具有协同作用-

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    Objective:To determine whether effects of active vitamin D deficiency and subsequent alterations of milk contents on tooth and mandible development in sucking pups. Methods:Comparison of tooth and mandible phenotypes between 25-Dihydroxyvi-tamin D3 1α-hydroxylase heterozygous[1α(OH)ase+/-] and homozygous[1α(OH)ase-/-] sucking mice at 2-week-old fed by 1α(OH)ase+/- or 1α(OH)ase-/- dames by radiography,micro-CT and histology. Results:Milk calcium levels were decreased in 1α(OH)ase-/- dames compared with that in 1α(OH)ase+/- dames. Dental volume and bone volume in mandibles were reduced in 1α(OH)ase-/- pups compared with those in their 1α(OH)ase+/- littermates. Dental volume and bone volume in mandibles were also reduced in pups fed by 1α(OH)ase-/ dames compared with pups fed by 1α(OH)ase+/- dames. Dental volume and bone volume in mandibles were the highest in 1α(OH)ase+/- pups fed by 1α(OH)ase+/- dames and were lowest in 1α(OH)ase-/- pups fed by 1α(OH)ase-/- dames. Conclusion:Active vitamin D and high milk calcium intake stimulate the mineralization and development of teeth and mandibles respectively and have cooperative action.

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王 骞,苗登顺.活性维生素 D缺乏导致牙齿和下颌骨的发育障碍[J].南京医科大学学报(自然科学版),2009,29(5):618-622

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  • 收稿日期:2009-01-19
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