Objective:To investigate effece of triptolide on the growth inbibitio of human endometrial cancer and to find out the role of triptolide on the expressions of Bcl-2 and VEGF. Methods:Human endometrial cancer cell line HEC-1B was seeded in the subcutaneous and a implant xenograft model was established by using nude mice. Mice were randomly divided into five groups,then treated with 0.9% NaCl solution,high,middle,and low dose triptolide(8,4,2 μg/d each one) and DDP 40 μg/d each one for up to 10~15 days respectively. Tumor size was measured in 2 dimensions at regular time-intervals and the expressions of Bcl-2 and VEGF in tumor tissues were detected by SABC. Results:After treatment, the size of the xenografts in high-dose triptolide group were 894.802+81.519 mm3,compared with1771.702+114 mm3 in the control group(P < 0.05,With inhibition rate of 50%). The expressions of Bcl-2 and VEGF in this group were significantly lower than that in the control group(P < 0.05). Conclusion:High dose triptolide can significantly inhibit the growth of the xenografts of endometrial cancer HEC-1B in nude mice. The mechanism may be closely related to down-regulating the expressions of Bcl-2 and VEGF in tumor cells by triptolide.