Objective:To study the success rate improvement of porcine myocardial infarction model produced by ligating coronary artery. Methods:16 young farm pigs were devided into operated(n = 10) and sham-operated(n = 6) groups. Operated animals were anesthetized,incubated,mechanically ventilated and lidocaine injected intravenously. The heart was exposed by sterile median sternotomy and pericardiotomy,and the left anterior descending(LAD) was ligated from two third distal to its origin,lidocaine was intravenously injected before,during and after operation. Sham-Operated animals underwent a similar procedure except for the LAD ligation. The electrocardiogram(ECG) was monitored throught the entire operation,coronary angioplasty,positron emission tomography(PET),triphenyltetrazolium chloride(TTC) staining and histopathological examination were performed 3 weeks later. Results:The success rat of porcine myocardial infarction model in the operated group was 90%. S-T elevation to single-phase curve appeared on the ECG after operation;coronary angiography showed that Medion and distal LAD was totally;PET demonstrated that radioactivity was sparse or absent in the left ventricular free wall and apex;light microscopy examination showed symmetrical fibrous connective tissue proliferation in the infracted area where the tissue is not stained by the TTC method. There were no abnormal results from macroscopic,ECG,PET and histopathological examination in sam-operated rats. Conclution:LAD ligation by sterile median sternotomy is a available and feasible method to increase the success rate of porcine myocardial infarction model, lidocaine intravenously used.