肝细胞肝癌中survivin?caspase-3和NF-κB的表达及其相关性
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江苏省卫生厅指导性科研课题(Z200718);南京医科大学科技发展基金项目(07NMUZ032)


Expressions of survivin,caspase-3 and NF-κB in hepatocellular carcinoma and their correlation
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    摘要:

    目的:探讨survivin-caspase-3-NF-κB在肝细胞肝癌(HCC)中的表达,及其与临床病理指标的关系-方法:采用免疫组织化学技术检测40例HCC组织及10例正常肝组织中survivin-caspase-3-NF-κB的表达情况-结果:survivin在HCC组织阳性表达率为67.5%,在对照组中不表达,两者比较有显著性差异(-字2=12.082,P < 0.05);门静脉癌栓者阳性表达率高于无门静脉癌栓者(-字2=5.405,P < 0.05);有远处转移者阳性表达率高于无远处转移者(-字2=4.596,P < 0.05)-caspase-3在HCC组织阳性表达率为35.0%,在对照组中表达率为80.0%,两者比较有显著性差异(-字2=4.875,P < 0.05)-NF-κB在HCC组织阳性表达率为77.5%,在对照组中不表达,两者比较有显著性差异(-字2=17.238,P < 0.05);中低分化阳性表达率高于高分化(-字2=4.198,P < 0.05)-caspase-3的表达与survivin的表达呈负相关(r=-0.679,P < 0.05);NF-κB的表达与survivin的表达呈正相关(r=0.519,P < 0.05)-结论:survivin-caspase-3-NF-κB在HCC的发生-发展中起着不同程度的作用;联合检测survivin-caspase-3-NF-κB,有助于对HCC恶性程度的判定及侵袭转移能力的评估,进而为HCC的预后分析及临床治疗提供依据-

    Abstract:

    Objective:To investigate the expressions of survivin,caspase-3 and NF-κB in hepatocellular carcinoma(HCC)and their relationship with clinical pathologic features of HCC. Methods:40 cases of HCC specimens were collected as study group and 10 cases of normal specimens as control. Immunohistochemcal method was used to detect the expressions of survivin,caspase-3 and NF-κB. Results:Positive expression rate of survivin was 67.5% in HCC study group,while negative in the control. There was significant difference between the study and normal control groups(-字2=12.082,P < 0.05). In the study group,the positive expression rate of survivin was higher in the group with oncogenic portal vein thrombosis than in the group without(-字2=5.405,P < 0.05). The positive rate of survivin was higher in the cases with extrahepatic metastasis than in coses without(-字2=4.596,P < 0.05). 35.0% of the study group expressed caspase-3,while 80.0% of the control group expressed caspase-3. Significant difference was found between these two groups(-字2=4.875,P < 0.05). 77.5% of the experimental group expressed NF-κB while negative in the control. There was significant difference between these two groups(-字2=17.238,P < 0.05). The positive expression rate of NF-κB was higher in the low differentiation group than those in the high differentiation group(-字2=4.198,P < 0.05). There was negative correlation between the expression of caspase-3 and survivin(r=-0.679,P < 0.05). However,the correlation between the expression of NF-κB and survivin was positive(r=0.519,P < 0.05). Conclusion:Since survivin,caspase-3 and NF-κB each has a different effect on the origin and development of HCCs,the combination of detection of these three factors will provide us a valuable clinical index for the degree of malignancy and capability of metastasis,it offers HCC a better treatment regimen and prognosis.

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秦 安,蔡 兵,王 彤,杨国仪,夏钰弘,梁加贝.肝细胞肝癌中survivin?caspase-3和NF-κB的表达及其相关性[J].南京医科大学学报(自然科学版),2009,29(7):953-957

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  • 收稿日期:2009-03-02
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