C反应蛋白自身抗体与急性冠脉综合征斑块不稳定的相关性研究
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A preliminary study between serum anti-CRP autoantibodies and plaque unstable in acute coronary syndrome
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    摘要:

    目的:探讨C反应蛋白(CRP)自身抗体与急性冠脉综合征(ACS)患者冠脉病变严重程度-斑块不稳定的相关性-方法:应用间接酶联免疫吸附法检测120例ACS,61例稳定型心绞痛(SAP)和120例对照者血清CRP自身抗体吸光度(A)值,并以对照组的95%可信区间A值作为判断CRP自身抗体阳性或阴性的界点-结果:ACS征组血浆CRP自身抗体A值水平(1.75 ± 1.09)显著高于SAP(1.27 ± 0.61)和对照组(0.88 ± 0.43),P < 0.001,并与冠状动脉病变积分无相关性(P > 0.05)-ACS组CRP自身抗体阳性比例(44.17%)显著高于SAP组(8.84%),P < 0.001-结论:CRP自身抗体不是反映ACS患者冠状动脉病变严重程度的指标,CRP自身抗体水平可能是随着斑块不稳定而变化的,与ACS患者斑块不稳定相关,但CRP自身抗体在ACS中的作用机制尚不明了-

    Abstract:

    Objective:To investigate the changes of serum anti-CRP autoantibodies(CRP-Ab) and their relationship in acute coronary syndrome (ACS) patients. Methods:Serum samples were taken from all patients with ACS(n=120),stable angina pain (SAP)(n=61) and subjects without coronary heart disease (NCAD) (n=120)subjects. The serum levels of CRP-Ab(IgG)were quantitatively measured by indirect ELISA assay. Absorbance(A) was measured at 405 nm. Positive cut-off values were calculated from the 95 th percentile of the A values in NCAD subjects. Results:The serum levels of CRP-Ab were greatly elevated in patients with ACS(1.75±1.09) compared with SAP(1.27±0.6.1) and NCAD(0.875±0.43) subjectes (P < 0.01,respectively). The positive tatio of CRP-Ab in ACS group(44.17%) are higher than SAP group(8.84%) (P < 0.001). There was no significant correlation between the serum level of CRP-Ab and the number of lesioned artery of coronary artery stenosis (P > 0.05). Conclusion:we found that autoantibodies to CRP are common in sera from patients with ACS. It is likely that this explains the relative of CRP response in patients with ACS.It can be excluded that anti-CRP autoantibodies have biological potentials of pathophysiological interest in ACS.

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戴 健,罗海明,杨志健,邓中龙,姚 望,周训杰,张寄南. C反应蛋白自身抗体与急性冠脉综合征斑块不稳定的相关性研究[J].南京医科大学学报(自然科学版),2009,29(7):996-999

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  • 收稿日期:2009-02-17
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