白细胞介素-1α-889C/T多态性与小儿癫痫易感性的关系
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

南京医科大学科技发展基金项目(07NMUM078)


Association of IL-1α-889C/T polymorphism with the risk of pediatric epilepsy
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨白细胞介素-1α-889C/T多态性与小儿癫痫易感性关系-方法:采用病例对照研究,选择117例小儿癫痫患者和95例健康儿童,应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)进行IL-1α-889C/T多态性检测,比较不同基因型与小儿癫痫风险的关系-结果:与携带-889 CC基因型者比较,携带至少1个-889 T等位基因者(即CT和TT基因型)小儿癫痫风险增加2.91倍(95%CI = 1.27~6.69),且有癫痫或热性惊厥家族史者,-889突变型使小儿癫痫风险增加6.83倍(95% CI = 2.30~20.29)-结论:IL-1α-889C/T多态性可能与小儿癫痫遗传易感性有关,并可显著增加家族史对小儿癫痫的危险性-

    Abstract:

    Objective:To explore the relationship between IL-1α-889C/T polymorphism and the susceptibility to pediatric epilepsy. Methods:IL-1α-889C/T polymorphism in 117 patients with pediatric epilepsy and 95 healthy individuals controls were analyzed with polymerase chain reaction restriction and fragment length polymorphism(PCR-RFLP). Results:Multivariate Logistic regression analysis revealed that individuals carrying at least one -889 T variant allele (CT + TT genotypes) had a significant increased risk for pediatric epilepsy (adjusted OR = 2.91,95% CI:1.27~6.69) , compared with the wild-type genotype (-889CC) . Furthermore, individuals with epilepsy or febrile seizures family history had a significantly higher risk (adjusted OR = 6.83, 95% CI: 2.30~20.29), compared with those with both CC genotypes. Conclusion:These findings support the hypothesis that IL-1α-889C/T polymorphism may contribute to the risk of developing pediatric epilepsy.

    参考文献
    相似文献
    引证文献
引用本文

陆海英,黄松明,张爱华,郑 帼,黄艳军.白细胞介素-1α-889C/T多态性与小儿癫痫易感性的关系[J].南京医科大学学报(自然科学版),2009,29(8):1153-1156

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2009-03-31
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期:
  • 出版日期:
通知关闭
郑重声明