新型超声造影剂对肝纤维化-肝硬化定量诊断的研究
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江苏省社会发展计划(BS2006075)


Study of new type of an ultrasound contrast agent in quantitative diagnosis of hepatic fibrosis and cirrhosis
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    目的:探讨新型超声造影剂对肝纤维化-肝硬化定量诊断的研究-方法:肝纤维化-肝硬化患者各20例,均经肝穿刺病理证实,正常对照组10例,无任何肝脏病史,采用实时灰阶超声造影,团注法注入声诺维(SonoVue),测定肝静脉到达时间(HVAT)及肝动脉到达时间(HAAT),两者相减得到肝动静脉渡越时间(HA-VTT)-结果:HA-VTT在正常对照组-肝纤维化组-肝硬化组间两两比较均有统计学意义(P < 0.05),肝硬化组HA-VTT较正常对照组明显缩短(P < 0.01)-结论:利用新型超声造影剂测量HA-VTT有望成为定量诊断肝纤维化-肝硬化的新方法-

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    Objective:To investigate the significance of contrast-enhanced ultrasound in quantitative diagnosis of liver fibrosis and cirrhosis. Methods:Twenty cases of liver fibrosis and 20 cases of liver cirrhosis proven by biopsy were enrolled in this study while 10 cases without liver disease history served as controls. A real time gray-scale contrast enhanced ultrasound was performed with SonoVue bolus injection to determine hepatic artery to vein transit time (HA-VTT). Results:There is a significant difference of the HA-VTT among the three groups(P < 0.05). HA-VTT in hepatic cirrhosis group was shorter than controls(P < 0.01). Conclusion:Determination of HA-VTT were considered to be a new diagnostic method in quantitative diagonosis of hepatic fibrosis and cirrhosis.

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庄 静,胡建群,王剑翔,蔡晓峰.新型超声造影剂对肝纤维化-肝硬化定量诊断的研究[J].南京医科大学学报(自然科学版),2009,29(8):1164-1166

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  • 收稿日期:2009-03-02
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