N-乙酰半胱氨酸对糖尿病肾病大鼠炎症反应的抑制作用
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常州市社会发展科技计划项目(CS2008210)


N-acetylcysteine inhibits the inflammation in diabetic nephropathy rats
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    目的:探讨N-乙酰半胱氨酸(NAC)对糖尿病肾病(DN)大鼠炎症反应的抑制作用-方法:制备DN大鼠模型,将动物随机分为正常对照组-DN组和NAC组-8周后测定尿白蛋白排泄率,血清高敏C反应蛋白(hs-CRP)-白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)水平,免疫组化方法检测肾组织NF-κB蛋白表达水平,观察肾脏病理标本-结果:①与正常对照组比较,DN组和NAC组尿白蛋白排泄率增多(P < 0.01),血清hs-CRP-IL-6和TNF-α水平升高(P < 0.01或P < 0.05),肾组织NF-κB蛋白表达水平升高(P < 0.01或P < 0.05),肾脏病理改变明显;②与DN组比较,NAC组尿白蛋白排泄率减少(P < 0.01),血清hs-CRP-IL-6和TNF-α水平降低(P < 0.05),肾组织NF-κB蛋白表达水平降低(P < 0.05)和肾脏病理改变较轻-结论:NAC对DN大鼠肾脏有保护作用,其部分机制与抑制炎症反应有关-

    Abstract:

    Objective:To investigate the inhibition of N-acetylcysteine(NAC) on the inflammation of diabetic nephropathy rats. Methods:A rat model of DN was established. The rats were divided into control group,DN group and NAC group randomly. Urinary albumin excretion rate(UAER),hs-CRP,IL-6 and TNF-α in serum were determined. The expression of NF-κB in renal tissue was detected by immunohistochemistry 8 weeks after treatment. Pathomorphologic changes of nephridial tissues were observed. Results:①Compared to control group,UAER,hs-CRP,IL-6 and TNF-α in serum were significantly higher(P < 0.01 or P < 0.05),activity of NF-κB in nephridial tissue increased(P < 0.01 or P < 0.05) and significant changes of pathomorphology in nephridial tissues were observed in DN group and NAC group. ②Compared to DN group,UAER,hs-CRP,IL-6 and TNF-α in serum were significantly lower(P < 0.05),activity of NF-κB in nephridial tissue was lower(P < 0.05) and improvement of pathomorphology in nephridial tissues were observed in NAC group. Conclusion:The protective effect of NAC on the kidney of the DN rats may be partly related with the inhibition on inflammation.

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刘同强,冯〓曦,李娟娟,汤京华,龚苏飞. N-乙酰半胱氨酸对糖尿病肾病大鼠炎症反应的抑制作用[J].南京医科大学学报(自然科学版),2009,29(11):1530-1533

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  • 收稿日期:2009-05-03
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