Objective:To compare the effect of right ventricular septum(RVS) pacing and that of right ventricular apex(RVA) pacing on the ventricular wall motion and cardiac function. Methods:RVS pacing was conducted in 20 patients,and RVA pacing was conducted in other 20 patients(sick sinus syndrome or Ⅲ° atrioventricular block). Three months after installment of the dualchamber pacemakers,tissue Doppler imaging was used to evaluated the time to peak in systolic phase of interventricular septum and left ventricular. CI,SV,LVDd and LVEF were also measured by conventional 2-Dimensional echocardiography. Results:Compared with RVA pacing,RVS pacing improved CI-SV- LVEF more. RVS pacing significantly shortened the time to peak in systolic phase and improved the consistency of wall motion as compared with the RVA pacing. Conclusion:Compared to RVA pacing,RVS pacing fulfiled a more physiological depolarization and significantly improveed ventricular performance,including cardiac function and cardiac synchronism.