Objective:To evaluate the efficacy and toxicity of docetaxel combined with oxaliplatin and xeloda on treatment of advanced gastric carcinoma. Methods:Thirty-two patients were treated with docetaxel 35 mg/m2 on day 1,8,combined with oxaliplatin 130 mg/m2 on day 1,and xeloda 1 250 mg/(m2·d) twice daily,on day 1~14,with 28 days as a course of treatment. All the patients were treated with more than two courses of chemotherapy. Results:All patients were assessable for toxicity,and 30 of 32 patients were assessable for response. In evaluable 30 patients,CR 1 case,PR 12 cases,SD 9 cases,and PD 8 cases. The response rate was 43.3%(13/30). Median TTP was 5.8 months. The major toxicities were bone suppression and alopecia. Conclusion:Docetaxel combined with oxaliplatin and xeloda are feasible,effective and safe for patients with advanced gastric carcinoma.