复方甘草酸苷联合川芎嗪治疗酒精性肝病的疗效观察
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Observation of curative effects of compound glycyrrhizin combined with ligustrazine on patients with alcoholic liver disease
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    摘要:

    目的:观察复方甘草酸苷联合川芎嗪治疗酒精性肝病的疗效-方法:将160例酒精性肝病患者随机分为对照组-复方甘草酸苷组-川芎嗪组及联合治疗组,治疗4周后观察肝功能-肝纤维化指标-转化生长因子β1(TGFβ1)-白细胞介素-6(IL-6)-瘦素(Leptin)及肿瘤坏死因子-α(TNF-α)-结果:各组治疗后肝功能较治疗前均显著好转,肝纤维化指标-TGFβ1-IL-6-Leptin及TNF-α较治疗前均显著下降(P < 0.05),对照组-复方甘草酸苷组及川芎嗪组之间治疗后肝功能-肝纤维化指标-TGFβ1-IL-6-Leptin及TNF-α无显著性差异(P > 0.05),联合治疗组治疗后肝功能较对照组-复方甘草酸苷组及川芎嗪组显著改善(P < 0.05),肝纤维化指标-TGFβ1-IL-6-Leptin及TNF-α较对照组-复方甘草酸苷组及川芎嗪组显著下降(P < 0.05)-结论:复方甘草酸苷联合川芎嗪治疗酒精性肝病有效-

    Abstract:

    Objective:To observe the curative effects of compound glycyrrhizin combined with ligustrazine on patients with alcoholic liver disease. Methods:160 cases of alcoholic liver disease were randomly divided into four groups:control group,compound glycyrrhizin group,ligustrazine group and combined treatment group. The parameters of hepatic function and fibrosis were observed four weeks after treatment. Results:The parameters of hepatic function were improved after treatment and fibrosis,TGFβ1,IL-6,Leptin,TNF-α after treatment in four groups were lower than those before treatment(P < 0.05). The parameters of hepatic function,fibrosis,TGFβ1,IL-6,Leptin and TNF-α after treatment among control group,compound glycyrrhizin group and ligustrazine group had no significance(P > 0.05). Compared with control group,compound glycyrrhizin group and ligustrazine group,the parameters of hepatic function,fibrosis,TGFβ1,IL-6,Leptin,TNF-α of combined treatment group after treatment were obviously improved(P < 0.05). Conclusion:Compound glycyrrhizin combined with ligustrazine are effective for the treatment of alcoholic liver disease.

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韩俊岭,韩〓莹,张春艳,李朝晖,曲磊红,李〓莉,郑〓岳.复方甘草酸苷联合川芎嗪治疗酒精性肝病的疗效观察[J].南京医科大学学报(自然科学版),2009,29(11):1607-1610

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  • 收稿日期:2009-05-05
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