胃束带术治疗2型糖尿病效果及其机制初探
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江苏省卫生厅资助科研课题(Z200709)


Effect of gastric banding on type 2 diabetes and its primary mechanisms
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    摘要:

    目的:通过观察胃束带术(gastric banding)治疗链脲佐菌素(STZ)诱发2型糖尿病大鼠模型的效果,来初步阐明其机制-方法:将42只成模2型糖尿病大鼠分为手术组(O组)12只;假手术组(S组)10只;饮食控制组(F组)10只;对照组(C组)10只-检测术前-术后1-2-3-4-8和16周的空腹血糖;空腹血浆瘦素(leptin);空腹血浆胰岛素水平(FINS);体重及进食量-结果:O组术后第16周空腹血糖下降至(12.6±3.7)mmol/L -空腹血浆胰岛素水平升至(42.7±9.2)mIU/L-空腹血浆瘦素降至(14.6±3.3)pg/ml-体重(212.6±15.1)g/只与术前相比均有统计学意义(P < 0.01)-O组血糖下降过程中与空腹血浆胰岛素成负相关(r=-0.881,P < 0.01),与空腹血浆瘦素呈正相关(r=0.784,P < 0.01)-F组与O组相比较,2组间空腹血浆胰岛素和空腹血浆瘦素在术后3-4周相比有统计学意义(P < 0.05),及体重术后3周2组相比有统计学意义(P < 0.05),血糖无组间差异(P > 0.05)-结论:胃束带术能降低2型糖尿病大鼠的血糖,饮食控制体重减轻可能是胃束带术改善2型糖尿病大鼠模型血糖的主要机制-其后血浆胰岛素及空腹血浆瘦素的水平改变在胃束带术治疗2型糖尿病机制中发挥着重大作用-

    Abstract:

    Objective:To observe the effect of gastric banding on STZ -induced type 2 diabetes rats model,and to primarily clarify its mechanism. Methods:42 type 2 diabetes rats were randomly allocated into operation group (group O) with 12 rats;sham group (group S) with 10 rats;diet control group(group F) with 10 rats and control group(group C) with 10 rats. Fasting glucose,fasting plasma leptin,fasting plasma insulin levels,fasting weight and food intake were measured before and after operation 1st,2nd,3 rd,4th,8th and 16 th week. Results:16 weeks after operation in the Group O,fasting glucose fell to(12.6±3.7)mmol/L,fasting plasma insulin increased to(42.7±9.2)mIU/L,fasting plasma leptin decreased to(14.6±3.3)pg/ml and weight declined to(212.6±15.1)g,had statistical significance compared with the levels of preoperation(P < 0.01). In the Group O,fasting plasma insulin was negatively correlated with fasting plasma glucose(r =-0.881,P < 0.01),and positively correlated with fasting plasma leptin(r = 0.784,P < 0.01).There was no significant difference between the Group F and O on fasting plasma insulin and leptin,excepte for the 3rd and the 4th week postoperation(P < 0.05). Weight had statistical difference after three weeks of operation in the Group O compared with that of Group F(P < 0.05). There was no difference on blood glucose between Group F and O after operation(P > 0.05). Conclusion:Gastric banding can reduce fasting glucose in STZ-induced type 2 diabetes rats. Diet control and Weight loss may be the major mechanism of blood glucose change in STZ-induced type 2 diabetes rats after Gastric banding operation.

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孙晓芳,王道荣,赵长勇.胃束带术治疗2型糖尿病效果及其机制初探[J].南京医科大学学报(自然科学版),2009,29(12):1716-

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  • 收稿日期:2009-05-29
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