食物对口服雷贝拉唑肠溶胶囊吸收的影响研究
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The absorption of rabeprazole enteric-coated capsules was influenced by food taken at difference time in healthy volunteers
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    摘要:

    目的:研究饮食对健康志愿者口服雷贝拉唑肠溶胶囊在体内吸收的影响-方法:2名健康志愿者通过自身对照,先后口服雷贝拉唑肠溶胶囊各20 mg,并分别于给药后2 h及4 h后进食标准餐-采用反相HPLC-UV法测定血中药物浓度-结果:健康志愿者口服雷贝拉唑肠溶胶囊后,2 h和4 h进食标准餐后的Cmax分别为(263.0±32.8)ng/ml和(360.6±105.0)ng/ml;Tmax分别为(6.5±0.7)h和(3.8±0.4)h;AUC0-10分别为(1203.1±228.0)μg·h/L和(1108.7±267.4)μg·h/L;T1/2分别为(3.2±0.21)h和(1.60±0.05)h-结论:食物可以影响雷贝拉唑肠溶胶囊的人体吸收,药物达峰时间明显延长-

    Abstract:

    Objective:To evaluate the influence of food taken at different time in absorption of rabeprazole enteric-coated capsules in healthy volunteers. Methods:Two volunteers were enrolled in the study,and they were given rabeprazole enteric-coated capsules (20mg) at two different time points successively by own control,and took standard breakfast 2 or 4 hours after administration. Results:The pharmacokinetic parameters were as follows:Cmax:(263.0±32.8)ng/ml and(360.6±105.0)ng/ml;Tmax:(6.5±0.7)h and(3.8±0.4)h;t1/2:(3.2±0.21)h and(1.60±0.05)h;AUC0-10:(1203.1±228.0)μg·h/L and (1108.7±267.4)μg·h/L. Conclusion:The absorption of rabeprazole enteric-coated capsule was influenced by food,and Cmax was increased apparently.

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欧〓宁,张宏文,王永庆,陈安九,袁红宇,李子艳,吴〓玲,刘〓云.食物对口服雷贝拉唑肠溶胶囊吸收的影响研究[J].南京医科大学学报(自然科学版),2010,(1):17-

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  • 收稿日期:2009-07-08
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