PET/CT与胸部诊断CT在乳腺癌术后随访中的比较
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江苏省教育科学“十一五”规划课题资助项目(D/2009/01/105)


Impact of 18F-FDG PET/CT compared with diagnostic CT on following-up breast cancer after surgery
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    目的:探讨PET/CT与胸部诊断CT在乳腺癌术后随访中的应用价值-方法:70例乳腺癌术后患者,共进行18F-脱氧葡萄糖(FDG)PET/CT检查81人次;同日行胸部诊断CT扫描-以活检或手术后病理或随访结果作为参考标准,比较PET/CT与胸部诊断CT图像-结果:其中31人次PET/CT及对应的胸部诊断CT图像均未见病灶-另外50人次共检出372个病灶-PET/CT的总体灵敏度-特异性-准确性-阳性预测值-阴性预测值分别为88.0%-50.0%-84.9%-95.3%-26.8%;而胸部诊断CT检查分别为60.5%-31.6%-57.5%-88.6%-8.3%-对淋巴结转移,PET/CT的灵敏度(100%)高于胸部诊断CT的灵敏度(52.3%)-对骨骼及胸壁软组织转移,PET/CT的灵敏度(98.1%)也高于胸部诊断CT的灵敏度(25.0%)-但是,PET/CT对肺转移灶检测的灵敏度(58.8%)低于胸部诊断CT(98.9%)-结论:对乳腺癌术后淋巴结-骨骼与软组织转移的检测PET/CT优于胸部CT-但PET/CT一次成像技术并不能取代胸部CT,对于怀疑肺部小结节转移的患者,胸部诊断CT扫描是必要的-有益的-

    Abstract:

    Objective:To compare the imaging characteristics of 18F-fluorodeoxyglucose (FDG) PET/CT with same day diagnostic CT on breast cancer patients after surgery. Method:70 breast cancer patients after surgery were enrolled to take 18F-FDG PET/CT for 81 times. All patients underwent PET/CT for diagnostic purposes followed by diagnostic CT in the region of chest with breath hold. Results:31 PET/CT and 31 diagnostic CT results didn’t show any significant lesion. Another 50 studies displayed 372 lesions. The sensitivity,specificity,accuracy,positive productive value,and negative productive value of PET/CT were 88.0%,50.0%,84.9%,95.3%,26.8%,and those of diagnostic CT were 60.5%,31.6%,57.5%,88.6%,8.3%. As far as lymph node metastases were concerned,the sensitivity for PET/CT was 100%,but for diagnostic CT was 52.3%. As for bone and soft tissue metastases,the sensitivity for PET/CT was 98.1%,compared with 25.0% of diagnostic CT. As for pulmonary nodal metastasis,the sensitivity for PET/CT was 58.8%,but for diagnostic CT was 98.9%. Conclusion:PET/CT accurately detects more malignant lesions than CT does for lymph node and bone and soft tissue metastases. However,the diagnostic CT with breath hold will have an advantage over PET/CT on pulmonary metastases,especial small pulmonary node.

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陈建伟,王〓杰,刘〓标,丁其勇,黄庆娟. PET/CT与胸部诊断CT在乳腺癌术后随访中的比较[J].南京医科大学学报(自然科学版),2010,(2):195-198213

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