Abstract:Objective:To study the expression of Foxd3 in cervical carcinoma(CC) and its significance. Methods:Reverse transcription PCR (RT-PCR) was employed to detect Foxd3 mRNA in 21 cases of cervical carcinoma and 15 cases of normal cervix tissues (NC),and tissue array and immunohistochemistry were used to analyze Foxd3 protein expression in 31 cases of cervical carcinoma and 12 cases of normal tissue. Results:The mRNA level of Foxd3 was higher in CC than that in NC (P < 0.05),and most of CC (29/31,93.5%) expressed Foxd3 protein. Conclusion:Cervical carcinoma cell with stem cell property existing in cervical CC tissues may be a potential target of CC therapy.
