Objective:To evaluate the early prognostic role of plasma brain natriuretic peptide(BNP)and monocyte chemoattractant protein-1(MCP-1)levels in patients with unstable angina(UA). Methods:Eighty-five cases UA without heart failure were divided into IB(n=25),IIB(n=30)and IIIB(n=30)groups according to Braunwald classification, and 20 cases stable angina pectoris(SAP)were chosen in the control group. Plasma samples for BNP and MCP-1 were obtained in the first 24 h. The incidences of main abnormal cardiac event(MACE)were recorded during 30 days. Results:In every UA groups,plasma levels of BNP and MCP-1 elevated significantly,and in comparison to those in the control group,there were statistically significant difference(all P < 0.05). Plasma levels of BNP and MCP-1 in IIIB group were higher than those in IIB group and IB group(all P < 0.05). The levels of BNP and MCP-1 were significantly higher in patients who had complex lesions compared with those who had simple lesions(P < 0.05). Multivariable logistic regression analysis revealed that BNP and MCP-1 were all risk factors for cardiac events(all P < 0.05). Conclusion:Measurement of BNP and MCP-1 are helpful in predicting the short-term prognosis in UA patients without heart failure.