髓过氧化物酶在子痫前期患者中表达水平的研究
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南京医科大学科技发展基金项目(06NMUM070)


Study of the expression of myeloperoxidase in patients with preeclampsia
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    摘要:

    目的:测定髓过氧化物酶(MPO)在子痫前期患者中的表达,探讨MPO在子痫前期发病中的可能作用-方法:应用生化比色法测定正常妊娠组(31例)-子痫前期轻度组(33例)和重度组(30例)子宫静脉血和外周血中MPO含量,同时应用免疫组化EnVision法测定上述患者胎盘组织中MPO表达水平-结果:①在子宫静脉血中,轻度和重度子痫前期MPO含量明显高于正常妊娠组(P < 0.01),子痫前期重度组高于轻度组(P < 0.01);②在外周血中,轻度和重度子痫前期MPO含量虽高于正常妊娠组,但统计学处理显示无显著性差异(P > 0.05);③在胎盘组织中,轻度和重度子痫前期胎盘组织MPO表达水平明显高于正常妊娠组(P < 0.01),重度组高于轻度组(P < 0.05)-结论:MPO在子宫静脉血和胎盘中的表达水平与子痫前期患者的病情严重程度相关,提示MPO可能在局部通过氧化应激参与了子痫前期的发病-

    Abstract:

    Objective:To determine the levels of of MPO expression in human serum and placenta during pregnancy and their correlation with the development of preeclampsia. Methods:Patients with mild preeclampsia(n=33)and severe preeclampsia(n=30)were recruited while thirty-one women with normal pregnancies served as controls.Serum samples from uterine venous blood and peripheral venous blood and placentas were collected. Serum concentrations of MPO were determined with a chromatography method whereas the expression of MPO in placentas was detected by immunohistochemistry. Results:① Serum levels of MPO in uterine venous blood from both mild and severe preeclampsia groups were significantly higher than those of healthy controls(P < 0.01),with the highest levels detected in severe preeclampsia group(P < 0.01). ② Although serum levels of MPO in the peripheral venous blood from both mild and severe preeclampsia groups were higher than those of healthy pregnant group,there were no significant differences among three groups. ③ The levels of MPO expression in placentas of preeclampsia groups were significantly higher than those of healthy pregnant women,with the highest levels detected in severe preeclampsia patients(P < 0.01;P=0.017). Conclusion:The increased levels of MPO in uterine venous blood and placentas are closely correlated with the development of preeclampsia,suggesting that MPO may play a role in the pathogenesis of preeclampsia via local oxidative stress.

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吴〓惠,徐友娣,陈〓嫒,王劲松,韩〓云.髓过氧化物酶在子痫前期患者中表达水平的研究[J].南京医科大学学报(自然科学版),2010,(3):416-419

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  • 收稿日期:2009-10-20
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