Objective:To observe the interventive effects of Astragalus Danshen compound on rat submandibular gland in a small model of Sjogren’s syndrome. Methods:Submandibular gland tissue was extracted from Wistar rat,and emulsificated with complete Freund’s adjuvant (CFA)after blending,then subcutaneously injected into the rats on the hind feet and both sides of the groin. After that,subcutaneous injection of DTP vaccine was performed on the back to enhance immunity,thus producing pathological changes and clinical manifestations of the salivary gland similar to human Sjogren’s syndrome. Traditional Chinese medicine Astragalus particles combined with Danshen were applied. Results:The rat model was treated for 7 weeks. Salivary flow was reduce(P < 0.05),significant weight loss was found(P < 0.05),and submandibular gland index increased(P < 0.05). Partial parameters were imroved on rat model treated with Astragalus Danshen. The Chinese herbal compound significantly increased salivary flow(P < 0.05),both in the low and high dose groups(P < 0.01). However,there was no significance in water drinking between the rat model and the saline control group(P > 0.05). Conclusion:Astragalus Danshen can increase body weight and saliva secretion in the rat model mimicking Sjogren’s syndrome.