Objective:To study effects of different durations of thromboembolism on hemodynamics,pulmonary arteriography and right ventricle myocardial pathology in a rabbit model with embolization of pulmonary lobar artery. Methods:Twenty four rabbits were randomly divided into control group,mild pulmonary thromboembolism(PE) model group and severe PE model group,with 8 rabbits each. PE was induced by infusing autologous blood clots(right jugular vein). Arterial blood gas were analyzed and the plasma’s concentrations of cTnI and NT-proBNP were examined by ELISA before and 1 h,2 h,4 h,8 h after injection,and the hemodynamic monitoring was used by homemade catheter with multi-channel physiological recorder. The pathological changes of the lung and right ventricle myocardium were examined with light microscope at 12 h after injection. Results:①hemodynamic monitoring showed that RV systolic pressures(RVSP)increased and MAP declined significantly in the severe PE model group,then gradually return to normal after 4 h. There were obviously differences between the severe PE model group and control group(P < 0.01) and no differences between the mild PE model group and control group(P > 0.05);②ELISA showed that NT-proBNP in the severe PE model group increased at 2 h,peaked at 8 h compared to those in the control group and the mild PE model group(P < 0.01). cTnI in severe PE model increased at 4 h,peaked at 8 h,but no obuious changes in control group and mild PE group;③ Histopathological study showed that injury of right ventricle myocardium and lung were obvious in severe PE model group with inflammatory cell infilitration,and also show there was vacuolar degeneration of right ventricle myocardiu in severe PE model group,but was less in mild PE model group. Conclusion:The change of cTnI,NT-proBNP and hemodynamic prove that severe PE results right ventricle dysfunction. We can use cTnI,NT-proBNP as facilitate triage of PE,and should pay attention to injury of right ventricle myocardium and RV dysfunction in clinic.