KLOTHO基因C-1818T多态性与中国苏皖地区汉族人群急性冠脉综合征的相关性分析
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常州市社会发展科技计划资助(CS2007232)


Association of KLOTHO gene C-1818T polymorphism with acute coronary syndrome
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    目的:探讨KLOTHO基因第4外显子C-1818T多态性与中国苏皖地区汉族人群急性冠状动脉综合征(acute coronary syndrome,ACS)的可能关系-方法:应用聚合酶链反应(polymerase chain reaction,PCR)及基因芯片(gene microarray)技术对375例ACS患者(ACS组)和235例经相关检查排除冠心病(CAD)者(对照组)进行KLOTHO基因C-1818T多态性的检测-结果:与对照组相比:①ACS患者CC-CT和TT基因型以及T等位基因型频率分布无显著差异;②老年人(≥60岁)-男性和老年男性ACS患者的CT基因型频率均明显升高(P值分别为0.031-0.035和0.041)-在调整相关危险因素并经多元Logistic回归分析后,CT基因型与老年人和老年男性ACS均存在相关关系(P值分别为0.010和0.047),与男性ACS无明显相关关系(P=0.103)-结论:在中国苏皖地区汉族人群中,KLOTHO基因C-1818T多态性CT基因型与老年和老年男性ACS的发病均存在相关性-

    Abstract:

    Objective:To investigate the possible association between the C-1818T polymorphism in exon 4 of KLOTHO gene and acute coronary syndrome(ACS)in the Chinese Han population of Suwan region. Methods:A case-control study was conducted,including 375 patients with ACS(ACS group)and 235 control subjects who were free from coronary artery disease by coherence checks(control group). The KLOTHO gene C-1818T polymorphism was determined by polymerase chain reaction(PCR)and gene microarray. Results:Compared with the control group,① The frequencies of CC,CT,TT genotypes and the T allele of the C-1818T in ACS group were not significantly different;②The prevalence of the CT genotype is obviously higher in elderly patients(age≥60 years),male and also the elderly male with ACS(P value was 0.031,0.035,0.041 respectively). Furthermore,after adjustment for conventional risk factors, multiple logistic regression analysis showed that the CT genotype was a significant risk factor for ACS in the elderly or elderly male carrier(P values were 0.010 and 0.047 respectively),and no association with ACS in male(P=0.103). Conclusion:The CT genotype of KLOTHO gene C-1818T polymorphism was associated with the susceptibility to ACS in the elderly(age≥60 years),especially in elderly male in the Chinese Han population of Suwan region.

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何国平,金鸣锋,杨〓进,王俊宏,戚传平,高〓磊,杨〓笛,张寄南. KLOTHO基因C-1818T多态性与中国苏皖地区汉族人群急性冠脉综合征的相关性分析[J].南京医科大学学报(自然科学版),2010,(7):936-941

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  • 收稿日期:2009-12-22
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