血清胸苷激酶1对乳腺癌辅助诊断及术后化疗效果评估的意义
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The significance of serum thymidine kinase 1 on assistant diagnosis and evaluation of chemotherapy effect on breast cancer patients operated
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    目的:探讨血清胸苷激酶1(thymidine kinase 1,TK1)检测对乳腺癌辅助诊断及术后化疗效果评估的意义-方法:应用免疫印迹—增强化学发光法(ECL)检测48例乳腺肿瘤患者的血清TK1水平,并对其中随访1~3个月的14例术后化疗的血清TK1水平进行检测-结果:10例完成4~6个周期化疗后的血清TK1降低并接近正常人水平,4例血清TK1未降反升-随访1年后,有1例发生骨转移-结论:血清TK1水平反映细胞增殖,与病灶大小有一定相关性,连续跟踪结果有利于对乳腺癌治疗效果的辅助诊断,对临床监视肿瘤疗效具有临床意义-

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    Objective:To evaluate the serum thymidine kinase 1(TK1)as a tumor marker for early tumor detection and monitoring chemotherapy effect on breast cancer patients operated. Methods:A sensitive chemiluminescence dot-blot assay was used to detect serum TK1 level in breast cancer patients(48 cases),including post-treated breast cancer patients(14 cases). Results:Forty eight cases had the pathological stage data. In order to exam the effect of chemotherapy,14 cases were chose to be followed-up for 1~3 months. Serous TK1 level in 10 of 14 cases was decreased to the level of healthy volunteers;four in 14 cases had a increased serous TK1 level,and one of them progressed bone metastasis one year later. Conclusion:Serous TK1 level has a correlation to the proliferation of breast cancer cell. Serum TK1 is a favorable and helpful marker for monitoring the response of chemotherapy.

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袁子育,刘晓安,凌立君,肇〓毅,王〓水.血清胸苷激酶1对乳腺癌辅助诊断及术后化疗效果评估的意义[J].南京医科大学学报(自然科学版),2010,(7):1002-1004

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  • 收稿日期:2010-05-11
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