甲型H1N1流感重症病例的危险因素
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Risk factors for severe cases of influenza A H1N1
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    摘要:

    目的:分析甲型H1N1流感患者发生重症临床表现的危险因素-方法:调查江苏省2009年6~12月间甲型H1N1流感确诊病例,利用统一设计的调查表收集信息,应用SAS 9.1.3软件进行单因素和多因素非条件Logistic回归分析重症危险因素和风险比值比(OR值)-结果:单因素Logistic回归分析显示,年龄-发病与首次就诊时间间隔-体重指数(BMI)-妊娠和慢性基础性疾病史为导致重症的影响因素(P < 0.01)-多因素Logistic回归分析显示,年龄-发病与首次就诊时间间隔-BMI和慢性基础性疾病史进入了最终模型(P < 0.05),其中慢性基础性疾病史对模型贡献最大(标准化回归系数β=0.72),其他依次为年龄(β=0.43)-BMI(β=0.35)和发病与首次就诊时间间隔(β=0.25)-因素合并分析显示,发病风险随着危险因素数量的增加而增加,存在剂量效应关系(P < 0.01)-结论:有慢性基础性疾病史-5岁以下儿童和年龄较大者-超重或肥胖者为甲型H1N1流感重症高危人群,感染甲型H1N1流感应尽量早期就诊,减少重症情况的发生-

    Abstract:

    Objective:To evaluate the risk factors for severe cases of influenza A H1N1. Methods:The confirmed cases of influenza A H1N1 during June to December 2009 in Jiangsu province were investigated using unified designed questionnaires. Univariate and multivariate non-conditional logistic regression were employed to analyze the risk factors and odds ratio(OR)with SAS 9.1.3. Results:Age,interval between incidence and first-visit,BMI,pregnant and chronic comorbid illness were identified as the risk factors of severe cases in univariate logistic regression models. And age,interval between incidence and first-visit,BMI and chronic comorbid illness got into the final multivariate logistic model. Among which,the contribution of chronic comorbid illness to the model was greatest(β=0.72),followed with age(β=0.43),BMI(β=0.35)and interval between incidence and first-visit(β=0.25). Joint effect analysis indicated a dose-response relationship between the increased risk and the amount of risk factors. Conclusion:Individuals with risk factors for severe cases of infulenza A H1N1 should receive earlytreatment.

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汤奋扬,霍〓翔,李〓亮,祖荣强,许〓可,祁〓贤,吴〓斌,嵇〓红,朱凤才,羊海涛.甲型H1N1流感重症病例的危险因素[J].南京医科大学学报(自然科学版),2010,(9):1262-1265

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  • 收稿日期:2010-04-13
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