Objective:To study expressions of cyclinA1,cyclinA2,cyclinD1 and cyclinE1 in postoperative reocurring patients of breast cancer and their clinical significances. Methods:Total 81 patients with breast cancer were selected,including 41 cases that developed a recurrence during 5-year follow-up as a study group,and 40 cases that were still alive without a recurrence as a control group. The total RNAs were extracted and identified from the paraffin-embedded tissues of all the cases. The expressions of cyclinA1,cyclinA2,cyclinD1 and cyclinE1 were studied by real-time quantitative RT-PCR array and analyzed by univariate cox regression. Results:The high expression were observed in cyclinA2 and cyclinD1. The positive rates of cyclinA2 and cyclinD1 were higher in postoperative reocurring patients of breast cancer than in postoperative non-reocurring patients,and there were statistical significance(P < 0.05). Their odds ratioes with 95% CI were 3.600(2.337-5.574)and 2.604(1.726-3.927)respectively. CyclinA2 and cyclinD1 were risk factors of postoperative reocurring patients of breast cancer. Conclusion:The high expressions of cyclinA2 and cyclinD1 played an important role in postoperative reocurring patients of breast cancer. They can be used as important referenced indexes of prognosis.