Objective:To investigate the expressions of survivin and NF-κB in Renal Cell Carcinoma(RCC),and their relationship with clinical pathologic features. Methods:There were 40 cases of RCC specimens as the RCC study group and 10 cases as normal control. The expressions of survivin and NF-κB were detected by immunohistochemical method. Results:There was 72.5% of positive expression rate of survivin in renal carcinoma study group,while negative expression in the control group. There was significant difference between the RCC study and normal control groups (P < 0.05). In the RCC study group,the positive expression rate of survivin was higher in TNM Ⅲ and Ⅳ stages than in TNM Ⅰ and Ⅱ stages (P < 0.05). There was 65.0% of positive expression rate of NF-κB in RCC study group,while 20% in the control. There was significant difference between those two groups (P < 0.05). The positive expression rate of NF-κB was higher in the lower differentiation group than in the higher differentiation group (P < 0.05),and higher in TNM Ⅲ and Ⅳ stages than in TNM Ⅰ and Ⅱ stages (P < 0.05). The correlation between the expressions of NF-κB and survivin was positive (r=0.590,P < 0.05). Conclusion:Since survivin and NF-κB each has a different effect on the origin and development of RCCs,the combination of these two factors’ detection will provide us a valuable clinical index for assessing malignancy and metastasis,which can offer RCC a better treatment regimen and prognosis.