急诊经皮冠状动脉介入治疗前应用替罗非班联合治疗糖尿病患者急性ST段抬高性心肌梗死的临床疗效
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To investigate the clinical effect and safety of tirofiban before percutaneuos coronary intervention in diabetes patients with acute ST-elevation myocardial infarction
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    摘要:

    目的:探讨糖尿病(diabetes,DM)患者发生急性ST段抬高心肌梗死(STEMI)后,在急诊经皮冠状动脉介入治疗(PCI)前应用国产替罗非班的有效性和安全性-方法:入选连续收治的86例有DM的STEMI患者,随机分为术前应用替罗非班组,41例,对照组(未应用替罗非班),45例,比较两组用药后30天及术后6个月心血管事件及出血并发症-结果:术后两组患者与穿刺有关并发症均为9例,术后1个月替罗非班组心血管事件6例,对照组15例(P=0.044),术后6个月罗非班组心血管事件9例,对照组19例(P=0.045),术后替罗非班组肌钙蛋白恢复时间(5.5±2.1)天,对照组(7.9±2.9)天(P=0.046)-结论:急诊PCI前应用国产替罗非班治疗有DM的STEMI患者安全有效,能减少术后1及6个月内心血管事件的发生-

    Abstract:

    Objective:To explore the feasibility and safety of inject tirofiban before percutaneuos coronary intervention in diabetes patients with acute ST-elevation myocardial infarction. Methods:Eighty-six diabetes patients wih acute myocardial infarction with ST segment elevation(STEMI) were randomly divided into tirofiban treatment group (n=41) and conventional treatment group (n=45). The events of cardiovascular diseases (CVD) within one month and six months were studied and compared. Results:There were 9 cases of puncture syndrome in tirofiban treatment group and 9 cases conventional treatment group,and there was no significant difference between two groups. There were 6 events of CVD in tirofiban treatment group and 15 events in conventional treatment group within 1 month(P=0.044),but there were 9 events of CVD in tirofiban treatment group and 19 events in conventional treatment group within 6 months (P=0.045). The recover time of troponinⅠ was (5.5±2.1) day in tirofiban treatment group and (7.9±2.9) day in conventional treatment group(P=0.046). Conclusion:Inject tirofiban before percutaneuos coronary intervention for STEMI with diabates is safety and feasibility,which can reduce events of CVD within one month and six months.

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郑若龙,陈新军,李伟章,钱惠东,蒋文龙,魏〓峰,徐卓文,张〓华,杨志健.急诊经皮冠状动脉介入治疗前应用替罗非班联合治疗糖尿病患者急性ST段抬高性心肌梗死的临床疗效[J].南京医科大学学报(自然科学版),2010,(9):1311-1314

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  • 收稿日期:2010-04-09
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