Objective: To investigate possible anti-asthma mechanisms of Xiansheng kechuanling Oral Liquid in asthma model rats.Methods:Sixty rats were randomly divided into normal control group, asthmatic model group and treatment group with 20 rats in each group. Rat asthma model were established by egg albumin induction. The rats of treatment group were treated with Xiansheng kechuanling Oral Liquid (10 ml/kg) once daily for 7 days continuously. The concentrations of IL-4, IL-5 and IL-13 in rat plasma were determined using ELISA. Results:The symptom of asthma in treatment group was more improved than that in model group. Furthermore, the concentrations of IL-4, IL-5 and IL-13 in plasma were significantly decreased in treatment group than those in model group. Conclusion:These findings suggest that Xiansheng kechuanling Oral Liquid inhibits IL-4, IL-5 and IL-13, which is likely to be one of its anti-asthma mechanisms.