Objective: To study the association of N-terminal pro-brainnatriuretic peptide(NT-proBNP), tumor necrosis factor-α(TNF-α) levels and the extent of coronary artery disease(CAD). Methods:One hundred and twenty CAD patients and thirty-five non-CAD patients were included in this study. All of the subjects were verified with coronary angiography. In the light of the types of CAD, CAD patients were assigned into three groups (SAP group, UAP group, AMI group), the comparisons of NT-proBNP and TNF-α levels were performed among the SAP, UAP, AMI and non-CAD groups. According to the number of suffered coronary artery, CAD patients were divided into groups of single-vessel, double-vessel and three-vessel. The associations of the levels of NT-proBNP and TNF-α with CAD severity were also evaluated. Results:We found a significant association between the types of CAD and changes of NT-proBNP or TNF-α level. We also observed that change of TNF-α, not NT-proBNP, was significantly associated with the number of vessels of suffered coronary artery. Conclusion:NT-proBNP and TNF-α may be useful markers of the extent of CAD.