Objective: To analyze the epidemiological feature of bacillary dysentery and the drug resistance of this pathogenic bacterium in Changzhou city from 2004 to 2009. Methods:Reported data of bacillary dysentery from 2004 to 2009 and pathogens detected through laboratory tests were analyzed by descriptive epidemiological method. Results:A total of 8096 cases of bacillary dysentery was reported during this period, and the average incidence was 35.26/100000. The disease can occur throughout all the year with an obvious seasonal trend, and the peak period for bacillary dysentery was July to September. The incidence of bacillary dysentery in urban areas was higher than that of two county-level cities. The incidence in males was higher than that in females, and the highest incidence rate was found in people of 0- to 4- year-old and 20-to 39-year-old. The reported data also showed that bacillary dysentery might occur in all different kinds of occupation, but most were scattered inhabiting children, workers and farmers. Total of 102 strains of Shigella flexneri and 11 strains of Shigella sonnei were detected in the laboratory. Both strains had high resistance to ampicillin, sinomin compositea and nalidixic acid. Conclusion:The incidence of bacillary dysentery in Changzhou city was gradually declining from 2004 to 2009, however, the prevention and control can not be ignored because the incidence of bacillary dysentery still maintains a certain level. In order to control the incidence of bacillary dysentery in Changzhou city, the health education in focus groups and the epidemic dynamic monitoring need to be enhanced in our future work.