手术治疗局限期小细胞肺癌患者的多因素预后分析
DOI:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

南京医科大学科技发展基金面上项目(2010NJMU017)


The multivariate analysis of prognosis in limited small cell lung cancer patients who underwent surgery
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的:探讨手术在局限期小细胞肺癌(SCLC)治疗中的作用,并分析影响其预后的因素,为小细胞肺癌手术治疗提供科学依据-方法:对本院1985年1月~2005年12月间收治的,且组织学病理以及影像学明确诊断为局限期小细胞肺癌的70例手术患者进行生存时间的分析,经Kaplan-Meier生存分析-Cox回归分析等方法,探讨影响小细胞肺癌手术疗效的相关预后因素- 结果:本组SCLC手术患者Ⅰ期-Ⅱ期以及Ⅲ期的5年生存率分别为63.8%-40.1%-33.2%-Cox单因素以及多因素分析表明:TNM分期-是否行化疗-手术方式和KPS评分是影响SCLC患者手术预后的独立危险因素-结论:以手术为主的治疗能使局限期SCLC患者受益,且TNM分期-是否行化疗-患者KPS评分是影响其预后的独立危险因素-

    Abstract:

    Objective:To explore the potential role of the surgical treatment in limited small cell lung cancer(SCLC) and analyze the factors affecting the prognosis. Methods:From January 1985 to December 2005, the survival rate of 70 in-patients with limited SCLC confirmed by histological pathology and imaging were analyzed. Furthermore, the related prognostic factors of patients underwent surgery were investigated by Kaplan-Meier estimator and Cox regression analysis. Results:The five-year survival rates of patients with stage Ⅰ,Ⅱ,Ⅲ SCLC were 63.8%, 40.1% and 33.2%, respectively. The Cox regression analysis indicated that TNM stage, application of platinum-based chemotherapy, operative manner and KPS scores were independent prognostic factors for SCLC patients after surgery. Conclusion: Patients with limited SCLC may benefit from the comprehensive treatment based on surgery. TNM stage, application of platinum-based chemotherapy, operative manner and KPS scores were independent prognostic factors for SCLC patients after surgery.

    参考文献
    相似文献
    引证文献
引用本文

吴清泉,赵 铭,陈其友,黄建峰.手术治疗局限期小细胞肺癌患者的多因素预后分析[J].南京医科大学学报(自然科学版),2011,(7):1032-1035

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2011-01-09
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期:
  • 出版日期:
通知关闭
郑重声明