中国汉族人群MTHFR C677T基因多态性与阿尔茨海默病发病风险的meta分析
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A meta-analysis on the association between the MTHFR gene C677T polymorphism and Alzheimer’s disease in Chinese population
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    摘要:

    目的:探索中国人群四氢叶酸还原酶(MTHFR)基因C677T多态性与阿尔茨海默病(AD)的关系-方法:对符合条件的研究进行meta分析,分别以1 048例AD患者和1 220例对照人群等位基因和基因型频率分布的OR值为统计量,采用固定或随机效应模型进行合并分析,并进行偏倚评估-结果:9篇文献符合条件纳入研究,入选文献无明显发表偏倚-数据合并结果显示:T等位基因-TT+TC基因型合并的OR值(95%CI)分别为1.21(1.07~1.37)和1.44(1.07~1.93)-结论:MTHFR C677T基因多态性与阿尔茨海默病发病具有相关性-

    Abstract:

    Objective:To investigate the association between methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism and Alzheimer’s disease(AD). Method:A meta-analysis including 1 048 cases and 1 220 controls in eligible studies were performed. The odds ratio(OR) of genotype and allele frequencies were regarded as statistics value, a random-effect or fixed-effect model was used in the analysis, and publication bias was assessed. Results:Nine papers met the criterion and were included in the meta study, and no significant publication bias was showed. The OR(95%CI) values of T/C and(TT+TC)/CC were 1.21(1.07~1.37) and 1.44(1.07~1.93). Conclusion:The MTHFR C677T polymorphism is associated with AD.

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华 烨,丁新生.中国汉族人群MTHFR C677T基因多态性与阿尔茨海默病发病风险的meta分析[J].南京医科大学学报(自然科学版),2011,(7):1040-1044

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  • 收稿日期:2011-02-24
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