2型糖尿病和高血压对血清前列腺特异抗原的影响
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The changes of serum prostate specific antigen levels in type 2 diabetes and hypertension patients
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    目的:观察2型糖尿病-高血压和血清前列腺特异抗原(PSA)之间的关系-方法:将2005~2010年在门诊和住院患者中大于40岁的男性分为糖尿病组(n=71)-高血压组(n=163)和对照组(n=378),分别填写调查表并进行血清PSA检测,对统计结果进行分析-结果:糖尿病组血清PSA水平低于对照组血清PSA,差异具有统计学意义(P < 0.05);高血压组血清PSA水平略高于对照组血清PSA,差异无统计学意义(P > 0.05)-结论:糖尿病患者血清PSA水平低于正常人群,应防止低PSA导致前列腺癌漏诊的发生-

    Abstract:

    Objective:To evaluate the changes of serum prostate specific antigen(PSA) levels in type 2 diabetes and hypertension patients. Methods:Totally 612 patients from 40 to 78 years old were divided into three groups: diabetes group, hypertension group and control group. All the patients were invited to complete a questionnaire and serum PSA test. Then a two-way ANOVA was performed to examine the association of type 2 diabetes, hypertension and PSA. Results:The serum PSA level of diabetes group was lower than that of control group and there was statistically significant difference between them(P < 0.05). The serum PSA level of hypertension group was higher than that of control group. But the difference between the two groups wasn’t statistically significant(P > 0.05). Conclusion:Our results suggest that the patients with type 2 diabetes experience lower serum PSA levels comparing with those without diabetes. Further research is needed to elucidate whether the difference results in a relatively lower less cancer detection among diabetic men.

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刘 坤,孟峻嵩,王 勇,庄海军,徐宗源,傅广波,王云炎,王功成,刘 靓.2型糖尿病和高血压对血清前列腺特异抗原的影响[J].南京医科大学学报(自然科学版),2011,(7):1050-1052

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  • 收稿日期:2011-01-02
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