中老年血清尿酸水平与代谢综合征的关系:因性别而不同
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江苏省科技厅社会发展基金重点项目资助(BE2009687)


The relationship between serum uric acid level and metabolic syndrome:differences by gender in the middle-aged and elderly Chinese
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    摘要:

    目的:探讨中老年人群血清尿酸(serum uric acid,SUA)与代谢综合征(metabolic syndrome,MetS)的相关性-方法:采用横断面研究,对某机关1 136例40~92岁人员进行调查与体检,收集血样检测血糖-血脂谱及SUA,分析SUA与MetS各主要组分之间的关系-结果:①SUA水平随着MetS组分的增加而增高;②高SUA人群具有更大的腰围(waist circumference,WC)-腰臀比(waist-to-hip ratio,WHR)-腰围身高比(waist-to-hight ratio,WHtR)和体质指数(body mass index,BMI),以及更低的高密度脂蛋白胆固醇(high density lipoprotein-cholesterol,HDL-C)水平(P < 0.01);③高SUA人群MetS患病率增高,女性组差异有显著性(P < 0.01);④相关性分析显示,校正年龄和性别后,SUA与WHtR-WC-甘油三酯(triglyeride,TG)-WHR和BMI呈显著正相关,而与HDL-C呈负相关;⑤多因素Logistic回归分析显示,高血压-中心性肥胖和高TG是高尿酸血症(hyperuricemia,HUA)的危险因素,女性是保护性因素-结论:中老年人群HUA多发,SUA水平升高与多种代谢指标异常密切相关,HUA是MetS的重要组成部分-SUA与MetS的相关性在女性人群中更为显著-

    Abstract:

    Objective: To explore the potential value of serum uric acid (SUA) level as a marker of metabolic syndrome (MetS) in middle-aged and elderly Chinese. Methods: A cross-sectional study was conducted to investigate 1 136 agency staff aged 40 to 92. Blood samples were collected for the determination of blood glucose,lipid profile and SUA. The relationship between MetS and SUA was analyzed. Results: The more components of MetS,the higher SUA levels. The prevalence of MetS elevated with the increasing SUA. SUA concentration was positively correlated with waist circumference(WC),waist-to-hip ratio(WHR),waist-to-hight ratio(WHtR),body mass index(BMI),triglyceride(TG),low density lipoprotein-cholesterol(LDL-C) and systolic blood pressure(SBP),and negatively correlated with hight density lipoprotein-cholesterol(HDL-C). Multiple variants Logistic regression analysis showed that abnormal hypertension,central obese and high TG were main factors to hyperuricemia(HUA),female was the protective factor. Conclusion: HUA is common in middle-aged and elderly Chinese,increased SUA level significantly correlates with metabolic disorders. HUA was intimately related to MetS components and might be an important factor of MetS. SUA is more closely associated with MetS in females than in males.

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唐 伟,高 远,俞 丹,周红文,杨 涛.中老年血清尿酸水平与代谢综合征的关系:因性别而不同[J].南京医科大学学报(自然科学版),2011,(9):1294-1298

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  • 收稿日期:2011-05-26
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